Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1229795..1230314 Replicon chromosome
Accession NZ_CP012731
Organism Streptococcus suis strain 90-1330

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2I5KI59
Locus tag AN924_RS06255 Protein ID WP_002940288.1
Coordinates 1230057..1230314 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A075STV3
Locus tag AN924_RS06250 Protein ID WP_029693774.1
Coordinates 1229795..1230055 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN924_RS06210 1225450..1226445 + 996 WP_062897089.1 protein jag -
AN924_RS06215 1226613..1226750 + 138 WP_002939016.1 50S ribosomal protein L34 -
AN924_RS06220 1226857..1227639 + 783 WP_079764350.1 TatD family hydrolase -
AN924_RS06225 1227602..1228192 + 591 WP_062897090.1 ribonuclease M5 -
AN924_RS06230 1228185..1228553 + 369 WP_062897091.1 hypothetical protein -
AN924_RS06235 1228651..1228938 + 288 WP_002940311.1 hypothetical protein -
AN924_RS06240 1228928..1229257 + 330 WP_062897092.1 type II toxin-antitoxin system RelE/ParE family toxin -
AN924_RS06245 1229264..1229719 + 456 WP_029943578.1 8-oxo-dGTP diphosphatase -
AN924_RS06250 1229795..1230055 + 261 WP_029693774.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AN924_RS06255 1230057..1230314 + 258 WP_002940288.1 Txe/YoeB family addiction module toxin Toxin
AN924_RS06260 1230328..1230858 + 531 WP_062897093.1 DUF1697 domain-containing protein -
AN924_RS06265 1230877..1231749 + 873 WP_002939007.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
AN924_RS06270 1231952..1233682 + 1731 WP_062897094.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10263.72 Da        Isoelectric Point: 7.2735

>T57081 WP_002940288.1 NZ_CP012731:1230057-1230314 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVESDRLCILSL
KDHYG

Download         Length: 258 bp

>T57081 NZ_CP012731:1230057-1230314 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAAGGTCAGGATAAGAAAACACTCAAGCGAAT
CAATAAGATTATCAAGGATATGCAACGACACCCGTTTGAAGGTATTGCCAAGCCAGAACCTTTGAAGTATGATTATCAGG
GTGCCTGGTCAAGAAGGATTGATGCGGAGAATCGGCTGATTTATATGGTGGAATCCGATCGGTTGTGCATCCTGTCGCTA
AAGGACCATTATGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9920.27 Da        Isoelectric Point: 5.1255

>AT57081 WP_029693774.1 NZ_CP012731:1229795-1230055 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNAYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp

>AT57081 NZ_CP012731:1229795-1230055 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTACATGAAAAAGGTCAATGACGAGTTTGAGCCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTGTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACGCCTACCTATCTCAGAAAGTCTTGCGTGGTATGGCTCAAGTCAAAGCAGGGCAAACTCAAGAACGA
AACTTGATAGAGGCAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5KI59

Antitoxin

Source ID Structure
AlphaFold DB A0A075STV3

References