Detailed information of TA system TA056986

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1668456..1669035
• Replicon: chromosome
• Accession: NZ_CP012692
• Organism: Staphylococcus aureus strain FORC_027

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: FORC27_RS08370
• Protein ID: WP_001025401.1
• Coordinates: 1668790..1669035 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1668456..1668821 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC27_RS08330	1665200..1665757	-	558	WP_000645045.1	DUF2815 family protein	-
FORC27_RS08335	1665783..1666949	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
FORC27_RS08340	1666946..1667308	-	363	WP_000279445.1	hypothetical protein	-
FORC27_RS08345	1667323..1667646	-	324	WP_000174995.1	hypothetical protein	-
FORC27_RS08350	1667725..1667886	-	162	WP_015986189.1	DUF1270 family protein	-
FORC27_RS08355	1667898..1668161	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
FORC27_RS08360	1668186..1668401	-	216	WP_001097552.1	hypothetical protein	-
FORC27_RS08365	1668456..1668821	+	366	WP_001128433.1	hypothetical protein	Antitoxin
FORC27_RS08370	1668790..1669035	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
FORC27_RS08375	1669091..1669300	+	210	WP_000642492.1	hypothetical protein	-
FORC27_RS08380	1669290..1669433	-	144	WP_000939498.1	hypothetical protein	-
FORC27_RS08385	1669448..1669891	-	444	WP_044414793.1	hypothetical protein	-
FORC27_RS08390	1669915..1670136	-	222	WP_031887876.1	DUF739 family protein	-
FORC27_RS08395	1670297..1671067	+	771	WP_031887877.1	helix-turn-helix domain-containing protein	-
FORC27_RS15905	1671079..1671225	+	147	WP_001049401.1	hypothetical protein	-
FORC27_RS08400	1671222..1671407	+	186	WP_000109189.1	hypothetical protein	-
FORC27_RS08405	1671477..1671644	+	168	WP_000705241.1	hypothetical protein	-
FORC27_RS08410	1671784..1672488	+	705	WP_000440838.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FORC27_RS08415	1672699..1673904	+	1206	WP_031766111.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ebp	1620391..1691529	71138

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T56986 WP_001025401.1 NZ_CP012692:c1669035-1668790 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T56986 NZ_CP012692:c1669035-1668790 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT56986 NZ_CP012692:1668456-1668821 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin