Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 118523..119180 | Replicon | plasmid p33676_IncA/C |
| Accession | NZ_CP012682 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain 33676 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | SE15cs_RS23930 | Protein ID | WP_000270043.1 |
| Coordinates | 118523..118873 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | SE15cs_RS23935 | Protein ID | WP_000124640.1 |
| Coordinates | 118878..119180 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SE15cs_RS23880 | 113834..114013 | + | 180 | Protein_136 | helix-turn-helix transcriptional regulator | - |
| SE15cs_RS23885 | 114078..114782 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| SE15cs_RS23890 | 114997..115494 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| SE15cs_RS23895 | 115497..115985 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| SE15cs_RS23900 | 116082..116417 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| SE15cs_RS23905 | 116432..116902 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| SE15cs_RS27110 | 116895..117266 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| SE15cs_RS27115 | 117277..117471 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| SE15cs_RS23925 | 117812..118360 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| SE15cs_RS23930 | 118523..118873 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| SE15cs_RS23935 | 118878..119180 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| SE15cs_RS23940 | 119207..119500 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| SE15cs_RS23945 | 119588..119860 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| SE15cs_RS23950 | 119918..120304 | - | 387 | Protein_149 | thermonuclease family protein | - |
| SE15cs_RS23955 | 120356..121060 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| SE15cs_RS23960 | 121379..122554 | + | 1176 | WP_002914189.1 | multidrug efflux RND transporter periplasmic adaptor subunit OqxA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..161461 | 161461 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 15014.38 Da Isoelectric Point: 12.8644
>T56953 WP_000270043.1 NZ_CP012682:118523-118873 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Download Length: 351 bp
>T56953 NZ_CP012682:118523-118873 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Antitoxin
Download Length: 101 a.a. Molecular weight: 12963.60 Da Isoelectric Point: 12.8000
>AT56953 WP_000124640.1 NZ_CP012682:118878-119180 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Download Length: 303 bp
>AT56953 NZ_CP012682:118878-119180 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|