Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 163953..164610 | Replicon | plasmid unnamed |
| Accession | NZ_CP012668 | ||
| Organism | Vibrio cholerae strain ICDC-VC661 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | AN947_RS20565 | Protein ID | WP_000270043.1 |
| Coordinates | 164260..164610 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | AN947_RS20560 | Protein ID | WP_000124640.1 |
| Coordinates | 163953..164255 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AN947_RS20510 | 159577..160005 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| AN947_RS20515 | 160062..160421 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| AN947_RS20520 | 160421..160867 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| AN947_RS20525 | 160864..161382 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| AN947_RS20530 | 161382..161612 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| AN947_RS20535 | 161599..162457 | + | 859 | Protein_183 | hypothetical protein | - |
| AN947_RS20545 | 162688..163215 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| AN947_RS20550 | 163273..163545 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| AN947_RS20555 | 163633..163926 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| AN947_RS20560 | 163953..164255 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| AN947_RS20565 | 164260..164610 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AN947_RS20570 | 164773..165321 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| AN947_RS20580 | 165662..165856 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| AN947_RS20585 | 165867..166238 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| AN947_RS20590 | 166231..166701 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| AN947_RS20595 | 166716..167051 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| AN947_RS20600 | 167148..167636 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| AN947_RS20605 | 167639..168136 | + | 498 | WP_000062185.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aph(3')-Ia / aac(3)-IId / catA2 / tet(D) / msr(E) / mph(E) / aadA2 / qacE / sul1 / aph(6)-Id / aph(3'')-Ib / sul2 / floR / blaTEM-1A | - | 1..180116 | 180116 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T56929 WP_000270043.1 NZ_CP012668:c164610-164260 [Vibrio cholerae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T56929 NZ_CP012668:c164610-164260 [Vibrio cholerae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT56929 WP_000124640.1 NZ_CP012668:c164255-163953 [Vibrio cholerae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT56929 NZ_CP012668:c164255-163953 [Vibrio cholerae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|