Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1865105..1865607 Replicon chromosome
Accession NZ_CP012635
Organism Escherichia coli strain SF-088

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0H2Z0A6
Locus tag AN203_RS09015 Protein ID WP_000767826.1
Coordinates 1865353..1865607 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag AN203_RS09010 Protein ID WP_001259255.1
Coordinates 1865105..1865356 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN203_RS08990 1860292..1861359 - 1068 WP_000080128.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
AN203_RS08995 1861359..1862429 - 1071 WP_000108997.1 histidinol-phosphate transaminase -
AN203_RS09000 1862426..1863730 - 1305 WP_001350692.1 histidinol dehydrogenase -
AN203_RS09005 1863736..1864635 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
AN203_RS29270 1864781..1864822 - 42 WP_010989201.1 his operon leader peptide -
AN203_RS09010 1865105..1865356 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
AN203_RS09015 1865353..1865607 + 255 WP_000767826.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
AN203_RS09020 1865690..1866514 + 825 WP_000754737.1 SDR family oxidoreductase -
AN203_RS09025 1866560..1867489 + 930 WP_000803363.1 LysR family transcriptional regulator -
AN203_RS29275 1867704..1867766 + 63 WP_010723108.1 membrane protein YoeI -
AN203_RS09030 1867756..1869114 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
AN203_RS09035 1869293..1870351 + 1059 WP_000492334.1 transport protein YeeE -
AN203_RS09040 1870365..1870592 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T56878 WP_000767826.1 NZ_CP012635:1865353-1865607 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRIIEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T56878 NZ_CP012635:1865353-1865607 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTATAGAGGAACACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT56878 WP_001259255.1 NZ_CP012635:1865105-1865356 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT56878 NZ_CP012635:1865105-1865356 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCACCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z0A6

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References