Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2483433..2483617 Replicon chromosome
Accession NZ_CP012593
Organism Staphylococcus aureus strain HOU1444-VR

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag IT770_RS12455 Protein ID WP_000482652.1
Coordinates 2483510..2483617 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2483433..2483493 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT770_RS12440 2478888..2479055 - 168 Protein_2405 hypothetical protein -
IT770_RS12445 2479286..2481019 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
IT770_RS12450 2481044..2482807 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2483433..2483493 + 61 - - Antitoxin
IT770_RS12455 2483510..2483617 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
IT770_RS12460 2483751..2484137 - 387 WP_000779360.1 flippase GtxA -
IT770_RS12465 2484405..2485547 + 1143 WP_031765234.1 glycerate kinase -
IT770_RS12470 2485607..2486266 + 660 WP_000831298.1 membrane protein -
IT770_RS12475 2486448..2487659 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
IT770_RS12480 2487782..2488255 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T56775 WP_000482652.1 NZ_CP012593:c2483617-2483510 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T56775 NZ_CP012593:c2483617-2483510 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT56775 NZ_CP012593:2483433-2483493 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References