Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2198364..2198580 Replicon chromosome
Accession NZ_CP012593
Organism Staphylococcus aureus strain HOU1444-VR

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag IT770_RS10965 Protein ID WP_001802298.1
Coordinates 2198476..2198580 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2198364..2198419 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT770_RS10945 2194570..2195235 - 666 WP_001024095.1 SDR family oxidoreductase -
IT770_RS10950 2195387..2195707 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
IT770_RS10955 2195709..2196686 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
IT770_RS10960 2196952..2198043 + 1092 WP_000495669.1 hypothetical protein -
- 2198364..2198419 + 56 - - Antitoxin
IT770_RS10965 2198476..2198580 - 105 WP_001802298.1 hypothetical protein Toxin
IT770_RS10970 2199097..2199267 + 171 WP_001792292.1 transposase -
IT770_RS10975 2199260..2199418 + 159 WP_001792784.1 hypothetical protein -
IT770_RS10980 2200076..2200933 - 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
IT770_RS10985 2201001..2201783 - 783 WP_000908182.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T56772 WP_001802298.1 NZ_CP012593:c2198580-2198476 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T56772 NZ_CP012593:c2198580-2198476 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT56772 NZ_CP012593:2198364-2198419 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References