Detailed information of TA system TA056766

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2010483..2010790
• Replicon: chromosome
• Accession: NZ_CP012593
• Organism: Staphylococcus aureus strain HOU1444-VR

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IT770_RS09900
• Protein ID: WP_011447039.1
• Coordinates: 2010614..2010790 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2010483..2010622 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT770_RS09860	2005828..2006088	+	261	WP_001791826.1	hypothetical protein	-
IT770_RS09865	2006141..2006491	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
IT770_RS09870	2007174..2007623	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
IT770_RS09875	2007718..2008052	-	335	Protein_1906	SH3 domain-containing protein	-
IT770_RS09880	2008699..2009190	-	492	WP_000920042.1	staphylokinase	-
IT770_RS09885	2009381..2010136	-	756	WP_000861026.1	CHAP domain-containing protein	-
IT770_RS09890	2010148..2010402	-	255	WP_000611512.1	phage holin	-
IT770_RS09895	2010454..2010561	+	108	WP_031762631.1	hypothetical protein	-
-	2010483..2010622	+	140	NuclAT_0	-	Antitoxin
-	2010483..2010622	+	140	NuclAT_0	-	Antitoxin
-	2010483..2010622	+	140	NuclAT_0	-	Antitoxin
-	2010483..2010622	+	140	NuclAT_0	-	Antitoxin
IT770_RS09900	2010614..2010790	-	177	WP_011447039.1	putative holin-like toxin	Toxin
IT770_RS09905	2010993..2011766	-	774	WP_025174055.1	staphylococcal enterotoxin type P	-
IT770_RS09910	2012187..2012561	-	375	WP_000340977.1	hypothetical protein	-
IT770_RS09915	2012617..2012904	-	288	WP_001262621.1	hypothetical protein	-
IT770_RS09920	2012950..2013102	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / see / hlb / groEL / hld	1955906..2090779	134873

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T56766 WP_011447039.1 NZ_CP012593:c2010790-2010614 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T56766 NZ_CP012593:c2010790-2010614 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT56766 NZ_CP012593:2010483-2010622 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin