Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2645662..2646167 Replicon chromosome
Accession NZ_CP012590
Organism Actinomyces sp. oral taxon 414 strain F0588

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0M4GSA1
Locus tag AM609_RS10610 Protein ID WP_053587254.1
Coordinates 2645662..2645916 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0M5JRY2
Locus tag AM609_RS10615 Protein ID WP_053587255.1
Coordinates 2645913..2646167 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM609_RS10595 2641620..2642471 - 852 WP_053587252.1 class I SAM-dependent methyltransferase -
AM609_RS10600 2642587..2642796 - 210 WP_053587253.1 hypothetical protein -
AM609_RS10605 2644062..2645468 - 1407 WP_083470799.1 citrate synthase -
AM609_RS10610 2645662..2645916 - 255 WP_053587254.1 Txe/YoeB family addiction module toxin Toxin
AM609_RS10615 2645913..2646167 - 255 WP_053587255.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AM609_RS10620 2646309..2647802 - 1494 WP_053587256.1 glycoside hydrolase family 1 protein -
AM609_RS10625 2648136..2649842 + 1707 WP_053587257.1 putative DNA binding domain-containing protein -
AM609_RS10630 2649940..2651127 - 1188 WP_083470801.1 succinyldiaminopimelate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9896.28 Da        Isoelectric Point: 9.3871

>T56760 WP_053587254.1 NZ_CP012590:c2645916-2645662 [Actinomyces sp. oral taxon 414]
VRLVWDPSAWGDYKYWQTADRRVLKRINTLIDACLRDPFAGVGKPERLKYGAPGAWSRRITDEHRLVYFVDGDDVVILQA
RYHY

Download         Length: 255 bp

>T56760 NZ_CP012590:c2645916-2645662 [Actinomyces sp. oral taxon 414]
GTGAGGCTCGTGTGGGACCCGTCCGCCTGGGGTGACTACAAGTACTGGCAGACGGCGGACCGCCGGGTCCTCAAGCGCAT
CAATACGCTCATCGACGCCTGTCTGCGCGATCCCTTCGCCGGTGTCGGCAAGCCCGAGCGCCTCAAGTACGGGGCTCCGG
GCGCGTGGTCGCGGCGCATCACCGACGAGCACCGCCTCGTCTACTTCGTCGACGGCGACGACGTCGTCATCCTCCAGGCC
CGCTATCACTATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9467.56 Da        Isoelectric Point: 5.8525

>AT56760 WP_053587255.1 NZ_CP012590:c2646167-2645913 [Actinomyces sp. oral taxon 414]
VSVSASQARKTLFPLIEQVNNDRDVVEIVSRKGSAVLMSAEEYAAWRETAYLFRSPANARRLLDAYERARAGQTEVHELD
RGTE

Download         Length: 255 bp

>AT56760 NZ_CP012590:c2646167-2645913 [Actinomyces sp. oral taxon 414]
GTGTCCGTGAGTGCCAGTCAGGCGCGCAAGACGTTGTTCCCGCTCATCGAGCAGGTCAACAACGACCGCGACGTCGTCGA
GATCGTTTCGCGCAAGGGCAGTGCCGTCCTCATGTCCGCCGAGGAGTACGCGGCCTGGCGCGAGACCGCCTACCTGTTCC
GCTCTCCCGCCAACGCCCGCAGGCTTCTCGACGCCTACGAGCGGGCGCGCGCGGGCCAGACCGAGGTTCACGAGCTCGAT
CGGGGGACTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4GSA1

Antitoxin

Source ID Structure
AlphaFold DB A0A0M5JRY2

References