Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2073670..2074172 Replicon chromosome
Accession NZ_CP012590
Organism Actinomyces sp. oral taxon 414 strain F0588

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0M4H6F9
Locus tag AM609_RS08395 Protein ID WP_053586924.1
Coordinates 2073670..2073927 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0M4GPK4
Locus tag AM609_RS08400 Protein ID WP_053586925.1
Coordinates 2073924..2074172 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM609_RS08375 2069490..2070239 + 750 WP_053586921.1 hypothetical protein -
AM609_RS08380 2070555..2071475 - 921 WP_053586922.1 hypothetical protein -
AM609_RS08385 2071494..2072333 - 840 WP_083470732.1 SDR family oxidoreductase -
AM609_RS08390 2072476..2073180 - 705 WP_053586923.1 CPBP family intramembrane metalloprotease -
AM609_RS08395 2073670..2073927 - 258 WP_053586924.1 Txe/YoeB family addiction module toxin Toxin
AM609_RS08400 2073924..2074172 - 249 WP_053586925.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AM609_RS08405 2074314..2076029 + 1716 WP_053586926.1 DUF885 domain-containing protein -
AM609_RS08410 2076051..2077232 - 1182 WP_083470734.1 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10022.58 Da        Isoelectric Point: 10.4198

>T56759 WP_053586924.1 NZ_CP012590:c2073927-2073670 [Actinomyces sp. oral taxon 414]
MRLVFTPNGWADYSSWLKADRRMLPRINRLIEDAMRHPFEGMGKPEPLRHALSGAWSRRITGEHRLVHLVDGDDLVILQA
RYHYK

Download         Length: 258 bp

>T56759 NZ_CP012590:c2073927-2073670 [Actinomyces sp. oral taxon 414]
ATGAGGCTGGTCTTCACGCCGAACGGCTGGGCCGACTACAGCTCCTGGTTGAAGGCGGACCGACGCATGCTGCCGCGGAT
CAACCGACTCATCGAGGATGCGATGCGCCATCCCTTCGAGGGGATGGGGAAGCCGGAACCGCTGAGGCATGCGCTGTCCG
GTGCCTGGTCGCGGCGTATCACCGGTGAGCATCGGCTCGTGCACCTCGTTGACGGCGACGATCTCGTGATTCTCCAGGCG
CGGTACCACTACAAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9028.09 Da        Isoelectric Point: 4.5277

>AT56759 WP_053586925.1 NZ_CP012590:c2074172-2073924 [Actinomyces sp. oral taxon 414]
MTVVSASEARANLFGLIERVNEDAAPVEITSRRGDAVLISRNEFEALEETAHLLRSPANAARLLESLTQAREGRVEEHEL
LS

Download         Length: 249 bp

>AT56759 NZ_CP012590:c2074172-2073924 [Actinomyces sp. oral taxon 414]
ATGACCGTCGTGTCGGCCAGCGAGGCCCGGGCGAATCTGTTCGGGCTCATTGAACGGGTCAACGAGGACGCGGCTCCCGT
GGAGATCACCTCGCGGCGCGGGGATGCCGTCCTCATCTCGCGCAACGAGTTCGAGGCGCTGGAGGAGACGGCTCACCTTC
TGCGCTCGCCCGCCAACGCCGCGCGCCTTCTGGAGAGTCTCACCCAGGCGCGCGAGGGGCGGGTCGAGGAGCACGAACTG
CTGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4H6F9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M4GPK4

References