Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-Phd
Location 2054418..2054923 Replicon chromosome
Accession NZ_CP012590
Organism Actinomyces sp. oral taxon 414 strain F0588

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0M3RJQ0
Locus tag AM609_RS08320 Protein ID WP_053586912.1
Coordinates 2054657..2054923 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0M4H6F3
Locus tag AM609_RS08315 Protein ID WP_053586911.1
Coordinates 2054418..2054660 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM609_RS08295 2050075..2051478 - 1404 WP_053586907.1 FtsX-like permease family protein -
AM609_RS08300 2051475..2052212 - 738 WP_053586908.1 ABC transporter ATP-binding protein -
AM609_RS08305 2052427..2053092 - 666 WP_053586909.1 response regulator transcription factor -
AM609_RS08310 2053089..2054210 - 1122 WP_053586910.1 histidine kinase -
AM609_RS08315 2054418..2054660 + 243 WP_053586911.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AM609_RS08320 2054657..2054923 + 267 WP_053586912.1 Txe/YoeB family addiction module toxin Toxin
AM609_RS16890 2055096..2055176 + 81 Protein_1672 competence protein TfoX -
AM609_RS08330 2055371..2055703 + 333 WP_053586914.1 hypothetical protein -
AM609_RS08335 2055700..2056107 + 408 WP_053586915.1 hypothetical protein -
AM609_RS15660 2056218..2059799 + 3582 WP_172680874.1 SIR2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10292.91 Da        Isoelectric Point: 10.1974

>T56758 WP_053586912.1 NZ_CP012590:2054657-2054923 [Actinomyces sp. oral taxon 414]
VSAWRIVYSKQARKDARRLASSGLKPKAQHLLDSIAADPFKTPPRYEKLVGDLAGCYSRRINIQHRLVYEVFPEEHTILV
LRMWTHYE

Download         Length: 267 bp

>T56758 NZ_CP012590:2054657-2054923 [Actinomyces sp. oral taxon 414]
GTGAGCGCCTGGCGCATCGTCTACTCCAAGCAGGCCCGCAAGGACGCGAGGAGGCTCGCATCCTCGGGTCTGAAGCCCAA
GGCTCAGCATCTGCTCGACAGTATCGCCGCGGACCCGTTCAAAACGCCGCCGCGCTACGAGAAGCTCGTCGGCGATCTCG
CTGGCTGTTACTCGCGCCGCATTAACATCCAGCACCGACTCGTCTACGAGGTCTTCCCCGAGGAGCACACGATCCTGGTT
CTGCGCATGTGGACCCACTACGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8751.69 Da        Isoelectric Point: 4.3444

>AT56758 WP_053586911.1 NZ_CP012590:2054418-2054660 [Actinomyces sp. oral taxon 414]
MSAVSATTARANLYHIIDQVNNESEPLTITGQRGNAVLVGENDWRAIQETLHLTSIPGMTRSIREARADGLDGACEELDW

Download         Length: 243 bp

>AT56758 NZ_CP012590:2054418-2054660 [Actinomyces sp. oral taxon 414]
ATGTCCGCTGTATCTGCAACCACCGCGCGAGCCAATCTTTACCACATCATCGATCAGGTCAACAACGAGTCCGAGCCGCT
GACCATCACCGGACAGCGCGGCAACGCCGTCCTCGTCGGCGAGAACGACTGGCGCGCCATCCAGGAGACGCTCCACCTCA
CCTCGATCCCCGGCATGACCCGCTCCATCCGCGAGGCGCGCGCGGACGGCCTCGACGGCGCCTGCGAAGAGCTCGACTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M3RJQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A0M4H6F3

References