Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2973681..2974435 | Replicon | chromosome |
| Accession | NZ_CP012554 | ||
| Organism | Citrobacter portucalensis strain P10159 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5B0T5Y1 |
| Locus tag | P10159_RS14190 | Protein ID | WP_048215202.1 |
| Coordinates | 2974124..2974435 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | P10159_RS14185 | Protein ID | WP_060683042.1 |
| Coordinates | 2973681..2974127 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P10159_RS14155 | 2968938..2969834 | + | 897 | WP_060683039.1 | sugar kinase | - |
| P10159_RS14160 | 2969868..2970671 | + | 804 | WP_060683040.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| P10159_RS14165 | 2970778..2971377 | + | 600 | WP_060683041.1 | glucose-1-phosphatase | - |
| P10159_RS14170 | 2971371..2972243 | + | 873 | WP_008786998.1 | virulence factor BrkB family protein | - |
| P10159_RS14175 | 2972240..2972677 | + | 438 | WP_003825289.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
| P10159_RS14180 | 2972722..2973663 | + | 942 | WP_003825286.1 | fatty acid biosynthesis protein FabY | - |
| P10159_RS14185 | 2973681..2974127 | - | 447 | WP_060683042.1 | helix-turn-helix domain-containing protein | Antitoxin |
| P10159_RS14190 | 2974124..2974435 | - | 312 | WP_048215202.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| P10159_RS14195 | 2974520..2975449 | - | 930 | WP_060683043.1 | alpha/beta hydrolase | - |
| P10159_RS14200 | 2975669..2975980 | + | 312 | WP_060683044.1 | hypothetical protein | - |
| P10159_RS14205 | 2975981..2976268 | + | 288 | WP_038635893.1 | helix-turn-helix domain-containing protein | - |
| P10159_RS14210 | 2976312..2977241 | - | 930 | WP_060683045.1 | formate dehydrogenase accessory protein FdhE | - |
| P10159_RS14215 | 2977238..2977873 | - | 636 | WP_003028686.1 | formate dehydrogenase cytochrome b556 subunit | - |
| P10159_RS14220 | 2977870..2978772 | - | 903 | WP_003825273.1 | formate dehydrogenase O subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12377.34 Da Isoelectric Point: 9.5337
>T56628 WP_048215202.1 NZ_CP012554:c2974435-2974124 [Citrobacter portucalensis]
MHVISRKPFNEAMLMYPNHQLALADLLNVLEKKTFIQPEEMKQYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRSHKI
FVKHIVSHAEYDKLTAYYRGNKE
MHVISRKPFNEAMLMYPNHQLALADLLNVLEKKTFIQPEEMKQYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRSHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T56628 NZ_CP012554:c2974435-2974124 [Citrobacter portucalensis]
TTGCATGTTATCAGCCGAAAACCTTTTAACGAGGCAATGCTCATGTATCCAAATCATCAGCTTGCTCTCGCTGATTTACT
GAATGTTTTGGAGAAAAAAACATTCATTCAGCCTGAAGAGATGAAGCAGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTAAGACTCATCTCCTACATAGATTTCAGGTCACATAAGATA
TTTGTCAAACATATCGTTTCCCATGCCGAATATGACAAACTGACAGCATATTATCGGGGTAATAAAGAATGA
TTGCATGTTATCAGCCGAAAACCTTTTAACGAGGCAATGCTCATGTATCCAAATCATCAGCTTGCTCTCGCTGATTTACT
GAATGTTTTGGAGAAAAAAACATTCATTCAGCCTGAAGAGATGAAGCAGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTAAGACTCATCTCCTACATAGATTTCAGGTCACATAAGATA
TTTGTCAAACATATCGTTTCCCATGCCGAATATGACAAACTGACAGCATATTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16707.00 Da Isoelectric Point: 6.7580
>AT56628 WP_060683042.1 NZ_CP012554:c2974127-2973681 [Citrobacter portucalensis]
MRTHRHMDTASAKKIVDTFSDAVKTIPLLGEDRNDTEYRRALALVEYLVDHDDLENPLFELLCARISKYEKHAPEFKALN
QHLEKTPSGVSVLRTLMDQYSLKASDLANELGSKSNVSNILNGRRALTVSHIKALAERFNLPADAFIE
MRTHRHMDTASAKKIVDTFSDAVKTIPLLGEDRNDTEYRRALALVEYLVDHDDLENPLFELLCARISKYEKHAPEFKALN
QHLEKTPSGVSVLRTLMDQYSLKASDLANELGSKSNVSNILNGRRALTVSHIKALAERFNLPADAFIE
Download Length: 447 bp
>AT56628 NZ_CP012554:c2974127-2973681 [Citrobacter portucalensis]
ATGAGAACGCATCGTCATATGGATACAGCCAGCGCAAAAAAGATTGTTGATACCTTCAGCGATGCGGTAAAAACCATCCC
ACTGTTGGGGGAAGACCGAAATGACACTGAGTATCGCAGGGCACTTGCGCTAGTGGAGTATCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTAAATATGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACACCCTCTGGCGTTTCAGTATTGCGTACGCTCATGGACCAATACAGTCTCAAAGCATCAGACCT
TGCCAACGAACTCGGTTCAAAATCGAACGTCAGCAACATCTTAAATGGTCGCAGAGCACTGACTGTAAGCCATATTAAAG
CGCTTGCAGAACGCTTTAATCTTCCGGCAGACGCATTCATCGAGTAG
ATGAGAACGCATCGTCATATGGATACAGCCAGCGCAAAAAAGATTGTTGATACCTTCAGCGATGCGGTAAAAACCATCCC
ACTGTTGGGGGAAGACCGAAATGACACTGAGTATCGCAGGGCACTTGCGCTAGTGGAGTATCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTAAATATGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACACCCTCTGGCGTTTCAGTATTGCGTACGCTCATGGACCAATACAGTCTCAAAGCATCAGACCT
TGCCAACGAACTCGGTTCAAAATCGAACGTCAGCAACATCTTAAATGGTCGCAGAGCACTGACTGTAAGCCATATTAAAG
CGCTTGCAGAACGCTTTAATCTTCCGGCAGACGCATTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|