Detailed information of TA system TA056622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 408020..408431
• Replicon: chromosome
• Accession: NZ_CP012549
• Organism: Campylobacter sp. RM16187

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CDOMF_RS02290
• Protein ID: WP_260953114.1
• Coordinates: 408279..408431 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CDOMF_RS02285
• Protein ID: WP_260952270.1
• Coordinates: 408020..408292 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDOMF_RS02260 (CDOMF_0446)	404365..405168	-	804	WP_260952266.1	tyrosine-type recombinase/integrase	-
CDOMF_RS02265 (CDOMF_0447)	405199..406587	-	1389	WP_260952267.1	restriction endonuclease subunit S	-
CDOMF_RS02270 (CDOMF_0448)	406696..406959	+	264	WP_169754966.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
CDOMF_RS02275	406940..407092	+	153	WP_260952268.1	hypothetical protein	-
CDOMF_RS02280	407064..407249	+	186	WP_260952269.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CDOMF_RS02285 (CDOMF_0450)	408020..408292	-	273	WP_260952270.1	helix-turn-helix transcriptional regulator	Antitoxin
CDOMF_RS02290	408279..408431	-	153	WP_260953114.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDOMF_RS02295 (CDOMF_0452)	408715..409872	-	1158	WP_260952271.1	site-specific integrase	-
CDOMF_RS02300 (CDOMF_0453)	411142..411534	+	393	WP_260952272.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (3-43)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-86)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5837.95 Da
• Isoelectric Point: 10.5435

>T56622 WP_260953114.1 NZ_CP012549:c408431-408279 [Campylobacter sp. RM16187]
IEGIARSIYCYEIGKRIIILLTFVKKTQKTPKSILNLAEQRLKEFKDGNR

Nucleotide

• Length: 153 bp

>T56622 NZ_CP012549:c408431-408279 [Campylobacter sp. RM16187]
ATAGAAGGAATAGCTAGAAGCATATATTGTTATGAAATCGGTAAAAGAATAATAATCCTACTAACTTTTGTTAAAAAAAC
ACAAAAGACGCCTAAAAGTATATTAAATTTGGCAGAACAAAGATTAAAGGAGTTTAAAGATGGGAACCGTTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10166.71 Da
• Isoelectric Point: 9.3643

>AT56622 WP_260952270.1 NZ_CP012549:c408292-408020 [Campylobacter sp. RM16187]
MGTVNFREVLKEELKNPEFKAQYDALEDEYKAIEALIDARNKAGLTQSEVAKRMGITQSAVARIESGAYNIKYKTFFNYI
KACGKRVAIV

Nucleotide

• Length: 273 bp

>AT56622 NZ_CP012549:c408292-408020 [Campylobacter sp. RM16187]
ATGGGAACCGTTAATTTTAGAGAAGTTTTAAAAGAGGAGCTAAAAAATCCGGAATTTAAAGCGCAATACGATGCGCTGGA
GGACGAATATAAAGCCATAGAAGCTTTAATAGACGCTAGAAACAAAGCCGGACTAACTCAAAGCGAAGTAGCTAAAAGGA
TGGGCATAACCCAATCAGCTGTAGCCAGAATAGAAAGCGGAGCGTATAATATAAAATACAAAACATTCTTTAACTACATA
AAAGCTTGCGGCAAAAGAGTAGCGATAGTGTGA