Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 878114..878778 Replicon chromosome
Accession NZ_CP012507
Organism Kocuria palustris strain MU14/1

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag KPaMU14_RS03875 Protein ID WP_053447114.1
Coordinates 878114..878482 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag KPaMU14_RS03880 Protein ID WP_053447115.1
Coordinates 878473..878778 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPaMU14_RS03845 873355..874644 + 1290 WP_053447109.1 CpaF family protein -
KPaMU14_RS03850 874641..875504 + 864 WP_053447110.1 type II secretion system F family protein -
KPaMU14_RS03855 875501..876442 + 942 WP_053447111.1 type II secretion system F family protein -
KPaMU14_RS12690 876484..876729 + 246 WP_006215278.1 hypothetical protein -
KPaMU14_RS03860 876722..877123 + 402 WP_024290839.1 pilus assembly protein -
KPaMU14_RS03865 877104..877550 + 447 WP_053447112.1 hypothetical protein -
KPaMU14_RS03870 877562..878017 + 456 WP_053447113.1 hypothetical protein -
KPaMU14_RS03875 878114..878482 + 369 WP_053447114.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KPaMU14_RS03880 878473..878778 + 306 WP_053447115.1 helix-turn-helix domain-containing protein Antitoxin
KPaMU14_RS03885 878809..879582 - 774 WP_053447116.1 enoyl-CoA hydratase -
KPaMU14_RS03890 879752..881428 + 1677 WP_053447117.1 long-chain-fatty-acid--CoA ligase -
KPaMU14_RS03895 881461..882159 - 699 WP_053447118.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-66)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13769.76 Da        Isoelectric Point: 6.4899

>T56599 WP_053447114.1 NZ_CP012507:878114-878482 [Kocuria palustris]
MTWIVDIELIAEWLTSLDGGSREQVVAAVELLEEHGPHLGRPVVDSVVGSRHKTMKELRPGFSGRSELRLLFALDPERRA
IILVAGDKAGAWKRWYRQSIPKADDLFDEHLRTLKGEGSTWP

Download         Length: 369 bp

>T56599 NZ_CP012507:878114-878482 [Kocuria palustris]
ATGACATGGATCGTGGACATCGAGCTGATCGCGGAATGGCTCACCTCCCTGGACGGCGGGTCGCGCGAGCAGGTCGTCGC
TGCCGTCGAGCTGCTGGAGGAGCATGGTCCGCACCTCGGTCGACCGGTGGTGGACAGTGTCGTGGGTTCCCGACACAAGA
CCATGAAGGAGCTTCGTCCAGGATTCTCGGGGCGGTCCGAGCTTCGTCTGCTCTTCGCGCTCGATCCTGAGCGCCGCGCG
ATCATCCTGGTCGCCGGCGACAAGGCCGGTGCCTGGAAGCGCTGGTACCGGCAGAGCATTCCGAAGGCTGATGACCTGTT
CGACGAGCACCTGCGGACCTTGAAGGGAGAAGGATCGACATGGCCATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11234.81 Da        Isoelectric Point: 7.2058

>AT56599 WP_053447115.1 NZ_CP012507:878473-878778 [Kocuria palustris]
MAMRMDEFLAQHPADRANIEAHKQRMLAEVRAFKLRELRQDAGLTQQQVAERIGVSQRQVSKIERGDLDSAKVGTIRGYL
EAVGGELALEFVSGDARVQVA

Download         Length: 306 bp

>AT56599 NZ_CP012507:878473-878778 [Kocuria palustris]
ATGGCCATGAGGATGGACGAGTTCCTCGCGCAGCATCCGGCGGATCGGGCGAACATCGAGGCGCATAAGCAGCGGATGCT
CGCGGAGGTGCGCGCCTTCAAGCTCCGCGAGCTGCGGCAGGACGCTGGGCTGACGCAGCAGCAGGTGGCCGAGCGCATCG
GCGTGTCGCAGCGGCAAGTGTCCAAGATCGAGCGCGGGGATCTGGACAGCGCCAAGGTCGGCACCATTCGCGGCTATCTC
GAAGCCGTGGGCGGCGAGCTGGCCCTGGAGTTCGTCAGCGGCGACGCCCGCGTGCAGGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References