56448

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1883961..1884475 Replicon chromosome
Accession NZ_CP012410
Organism Leptotrichia sp. oral taxon 212 strain W10393

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2JBV7
Locus tag AMK43_RS08645 Protein ID WP_053393070.1
Coordinates 1883961..1884218 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A109W7W4
Locus tag AMK43_RS08650 Protein ID WP_053393071.1
Coordinates 1884218..1884475 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMK43_RS08620 1879761..1880753 - 993 WP_172673342.1 hypothetical protein -
AMK43_RS08625 1880734..1881540 - 807 WP_053393066.1 protein-ADP-ribose hydrolase -
AMK43_RS08630 1881621..1882061 - 441 WP_053393067.1 Rrf2 family transcriptional regulator -
AMK43_RS08635 1882346..1882852 - 507 WP_053393068.1 hypothetical protein -
AMK43_RS08640 1882920..1883909 - 990 WP_053393069.1 Gfo/Idh/MocA family oxidoreductase -
AMK43_RS08645 1883961..1884218 - 258 WP_053393070.1 Txe/YoeB family addiction module toxin Toxin
AMK43_RS08650 1884218..1884475 - 258 WP_053393071.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AMK43_RS08655 1884619..1885596 - 978 WP_053393072.1 AraC family transcriptional regulator -
AMK43_RS08660 1885631..1886449 - 819 WP_053393073.1 oxidoreductase -
AMK43_RS08665 1886632..1887096 - 465 Protein_1698 DUF1211 domain-containing protein -
AMK43_RS08670 1887274..1888560 - 1287 WP_053393074.1 hypothetical protein -
AMK43_RS08675 1888696..1889403 - 708 WP_053393075.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10252.79 Da        Isoelectric Point: 9.4152

>T56448 WP_053393070.1 NZ_CP012410:c1884218-1883961 [Leptotrichia sp. oral taxon 212]
MNLIWNNEAWEEYIQWQKQDKKIVKKINEIIKDIKRNGNEGIGKPEPLKHELNGYWSRRITDKHRFIYKLTETAIVVIAC
ANHYE

Download         Length: 258 bp

>T56448 NZ_CP012410:c1884218-1883961 [Leptotrichia sp. oral taxon 212]
ATGAATCTAATTTGGAATAATGAGGCTTGGGAAGAATATATCCAGTGGCAAAAACAGGATAAAAAAATAGTTAAAAAAAT
AAATGAAATAATAAAGGATATTAAAAGAAATGGCAATGAGGGGATAGGGAAGCCGGAGCCTTTAAAACATGAACTGAATG
GATATTGGAGCAGAAGAATTACTGATAAGCACAGGTTTATATATAAACTGACAGAAACAGCTATAGTAGTTATTGCCTGT
GCAAATCATTATGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10141.46 Da        Isoelectric Point: 4.6909

>AT56448 WP_053393071.1 NZ_CP012410:c1884475-1884218 [Leptotrichia sp. oral taxon 212]
MIATNYSNVRNNLKKYCDKATDDYETVIITRKNDKNVVLMSEEEYNNLMENLYIMSNKKYYNELLKRKEEVEAGNVQIHD
IIEVE

Download         Length: 258 bp

>AT56448 NZ_CP012410:c1884475-1884218 [Leptotrichia sp. oral taxon 212]
ATGATAGCTACAAATTATTCAAATGTGAGAAACAATTTAAAAAAATATTGTGATAAGGCAACGGATGATTATGAAACAGT
CATCATAACAAGAAAAAATGATAAAAATGTGGTACTGATGAGTGAAGAGGAGTATAACAATTTGATGGAAAATCTTTACA
TCATGTCAAATAAGAAATATTACAATGAACTATTAAAAAGAAAAGAAGAAGTAGAGGCGGGAAATGTACAGATACATGAT
ATAATTGAGGTGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2JBV7

Antitoxin

Source ID Structure
AlphaFold DB A0A109W7W4

References