Detailed information of TA system TA056446

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2504284..2504464
• Replicon: chromosome
• Accession: NZ_CP012409
• Organism: Staphylococcus aureus subsp. aureus Tager 104

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: Tgr_RS15325
• Protein ID: WP_001801861.1
• Coordinates: 2504369..2504464 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2504284..2504341 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Tgr_RS12675	2502099..2502542	+	444	WP_000747798.1	DUF1433 domain-containing protein	-
Tgr_RS12680	2502542..2502985	+	444	WP_000731420.1	DUF1433 domain-containing protein	-
Tgr_RS12685	2502985..2503428	+	444	WP_000728661.1	DUF1433 domain-containing protein	-
Tgr_RS15365	2503998..2504153	-	156	WP_001215823.1	hypothetical protein	-
-	2504284..2504341	+	58	-	-	Antitoxin
Tgr_RS15325	2504369..2504464	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
Tgr_RS12690	2504609..2504845	+	237	WP_000251969.1	IS3 family transposase	-
Tgr_RS12695	2504851..2505084	+	234	Protein_2402	IS3 family transposase	-
Tgr_RS12700	2505252..2505541	+	290	Protein_2403	hypothetical protein	-
Tgr_RS12705	2505552..2505728	+	177	WP_000375478.1	hypothetical protein	-
Tgr_RS12710	2505730..2505915	+	186	WP_000809860.1	hypothetical protein	-
Tgr_RS12715	2506246..2506818	-	573	WP_000414218.1	hypothetical protein	-
Tgr_RS12720	2506919..2507260	-	342	WP_000627534.1	DUF3969 family protein	-
Tgr_RS12725	2507301..2507927	-	627	WP_000669045.1	hypothetical protein	-
Tgr_RS12730	2508003..2508998	-	996	WP_020977362.1	DUF4352 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2504609..2504845	236

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T56446 WP_001801861.1 NZ_CP012409:c2504464-2504369 [Staphylococcus aureus subsp. aureus Tager 104]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T56446 NZ_CP012409:c2504464-2504369 [Staphylococcus aureus subsp. aureus Tager 104]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT56446 NZ_CP012409:2504284-2504341 [Staphylococcus aureus subsp. aureus Tager 104]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin