Detailed information of TA system TA056442

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2351321..2351659
• Replicon: chromosome
• Accession: NZ_CP012409
• Organism: Staphylococcus aureus subsp. aureus Tager 104

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: Tgr_RS15010
• Protein ID: WP_011447039.1
• Coordinates: 2351321..2351497 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2351485..2351659 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Tgr_RS11735	2349007..2349159	+	153	WP_001000058.1	hypothetical protein	-
Tgr_RS11740	2349205..2349492	+	288	WP_001262621.1	hypothetical protein	-
Tgr_RS11745	2349548..2349922	+	375	WP_000340977.1	hypothetical protein	-
Tgr_RS11750	2350343..2351122	+	780	WP_029754109.1	staphylococcal enterotoxin type P	-
Tgr_RS15010	2351321..2351497	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2351485..2351659	-	175	-	-	Antitoxin
Tgr_RS11760	2351709..2351963	+	255	WP_000611512.1	phage holin	-
Tgr_RS11765	2351975..2352730	+	756	WP_000861026.1	CHAP domain-containing protein	-
Tgr_RS11770	2352921..2353412	+	492	WP_000920042.1	staphylokinase	-
Tgr_RS11775	2354063..2354397	+	335	Protein_2255	SH3 domain-containing protein	-
Tgr_RS11780	2354492..2354941	-	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
Tgr_RS11785	2355624..2355974	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
Tgr_RS11790	2356027..2356287	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / see / sak / chp / scn	2308474..2355974	47500

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T56442 WP_011447039.1 NZ_CP012409:2351321-2351497 [Staphylococcus aureus subsp. aureus Tager 104]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T56442 NZ_CP012409:2351321-2351497 [Staphylococcus aureus subsp. aureus Tager 104]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT56442 NZ_CP012409:c2351659-2351485 [Staphylococcus aureus subsp. aureus Tager 104]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin