Detailed information of TA system TA056435

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1905384..1905901
• Replicon: chromosome
• Accession: NZ_CP012409
• Organism: Staphylococcus aureus subsp. aureus Tager 104

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2S6D1N9
• Locus tag: Tgr_RS09345
• Protein ID: WP_000113263.1
• Coordinates: 1905635..1905901 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: Tgr_RS09340
• Protein ID: WP_000584498.1
• Coordinates: 1905384..1905635 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Tgr_RS09310	1901086..1901805	+	720	WP_000479576.1	amino acid ABC transporter permease	-
Tgr_RS09315	1901802..1902533	+	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
Tgr_RS09320	1902630..1903880	-	1251	WP_001012239.1	FemA/FemB family glycyltransferase FmhA	-
Tgr_RS09325	1904135..1904497	+	363	WP_000819844.1	DUF4467 domain-containing protein	-
Tgr_RS09330	1904516..1905115	+	600	WP_000162810.1	DsbA family protein	-
Tgr_RS09335	1905122..1905213	+	92	Protein_1787	hypothetical protein	-
Tgr_RS09340	1905384..1905635	+	252	WP_000584498.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Tgr_RS09345	1905635..1905901	+	267	WP_000113263.1	Txe/YoeB family addiction module toxin	Toxin
Tgr_RS09350	1906195..1907745	+	1551	WP_029754332.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
Tgr_RS09355	1907931..1908398	+	468	WP_000153340.1	SRPBCC domain-containing protein	-
Tgr_RS09360	1908485..1908667	+	183	WP_000079140.1	hypothetical protein	-
Tgr_RS09365	1908870..1909694	+	825	WP_000594640.1	formate/nitrite transporter family protein	-
Tgr_RS09370	1910159..1910695	+	537	WP_000185901.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.01 Da
• Isoelectric Point: 10.1628

>T56435 WP_000113263.1 NZ_CP012409:1905635-1905901 [Staphylococcus aureus subsp. aureus Tager 104]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T56435 NZ_CP012409:1905635-1905901 [Staphylococcus aureus subsp. aureus Tager 104]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGTTATTATAGTAGACGTATCAATCACGAACATAGATTGGTCTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9449.64 Da
• Isoelectric Point: 4.3407

>AT56435 WP_000584498.1 NZ_CP012409:1905384-1905635 [Staphylococcus aureus subsp. aureus Tager 104]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNLNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT56435 NZ_CP012409:1905384-1905635 [Staphylococcus aureus subsp. aureus Tager 104]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCTAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGAAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• AlphaFold DB: A0A2S6D1N9