Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2033022..2033456 Replicon chromosome
Accession NZ_CP012401
Organism Azospirillum thiophilum strain BV-S

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AL072_RS33325 Protein ID WP_082108956.1
Coordinates 2033334..2033456 (-) Length 41 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AL072_RS09480 Protein ID WP_045580537.1
Coordinates 2033022..2033309 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL072_RS09455 2028486..2028752 + 267 WP_082108957.1 hypothetical protein -
AL072_RS09460 2029021..2029281 - 261 WP_045580541.1 BrnA antitoxin family protein -
AL072_RS09465 2029378..2029623 + 246 WP_045580540.1 hypothetical protein -
AL072_RS09470 2030286..2031335 + 1050 WP_045580539.1 hypothetical protein -
AL072_RS09475 2031339..2031617 + 279 WP_045580538.1 hypothetical protein -
AL072_RS34890 2031617..2031784 + 168 WP_158511051.1 hypothetical protein -
AL072_RS34895 2031799..2032083 - 285 WP_152646953.1 hypothetical protein -
AL072_RS34235 2032126..2032689 - 564 WP_144428184.1 hypothetical protein -
AL072_RS34900 2032837..2033007 + 171 WP_158511052.1 hypothetical protein -
AL072_RS09480 2033022..2033309 - 288 WP_045580537.1 HigA family addiction module antidote protein Antitoxin
AL072_RS33325 2033334..2033456 - 123 WP_082108956.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL072_RS09485 2033607..2034650 + 1044 WP_045580536.1 hypothetical protein -
AL072_RS09490 2034650..2035213 + 564 WP_045580535.1 hypothetical protein -
AL072_RS33330 2035267..2036262 + 996 WP_082108811.1 DUF4062 domain-containing protein -
AL072_RS09495 2036652..2037470 + 819 WP_045580534.1 hypothetical protein -
AL072_RS09500 2037467..2038087 + 621 WP_045580533.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2023806..2088028 64222


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-40)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-88)


Sequences

Toxin        


Download         Length: 41 a.a.        Molecular weight: 4750.37 Da        Isoelectric Point: 6.7182

>T56430 WP_082108956.1 NZ_CP012401:c2033456-2033334 [Azospirillum thiophilum]
MTALKGDRAGQHSIRITDQWRIVFIWRDGVTHEVEIVDYH

Download         Length: 123 bp

>T56430 NZ_CP012401:c2033456-2033334 [Azospirillum thiophilum]
CTGACGGCGCTGAAGGGCGACCGCGCCGGACAGCACAGCATTCGGATCACCGACCAATGGCGCATCGTCTTCATCTGGCG
CGATGGTGTCACGCACGAGGTCGAAATCGTCGATTACCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10527.08 Da        Isoelectric Point: 6.8802

>AT56430 WP_045580537.1 NZ_CP012401:c2033309-2033022 [Azospirillum thiophilum]
MRIKTHPGEVLREEFLVPLDLSAHALALALRVPATRIGEIVNERRGITADTALRLARYFGTTPEFWLNLQMAHDLSATAA
DHGEEIQRSIAPRAA

Download         Length: 288 bp

>AT56430 NZ_CP012401:c2033309-2033022 [Azospirillum thiophilum]
ATGCGGATCAAGACCCACCCCGGCGAGGTTCTGCGCGAAGAGTTCCTCGTCCCGCTCGATCTCTCGGCCCATGCGCTGGC
CCTGGCTCTGCGCGTGCCGGCGACCCGCATCGGGGAAATCGTCAACGAACGACGCGGCATCACCGCCGATACCGCCTTGC
GGCTGGCGCGCTATTTCGGCACCACGCCGGAATTCTGGCTGAACCTTCAGATGGCGCATGACCTGTCCGCCACCGCCGCC
GACCATGGCGAGGAAATCCAGCGCAGCATCGCCCCCCGCGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References