Detailed information of TA system TA056416

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1387038..1387635
• Replicon: chromosome
• Accession: NZ_CP012393
• Organism: Neisseria meningitidis strain DE8555

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: DE8555_RS07235
• Protein ID: WP_002242826.1
• Coordinates: 1387357..1387635 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DE8555_RS07230
• Protein ID: WP_002221020.1
• Coordinates: 1387038..1387349 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DE8555_RS07205	1382304..1382630	+	327	WP_002238081.1	GPW/gp25 family protein	-
DE8555_RS07210	1382651..1383538	+	888	WP_002238082.1	baseplate J/gp47 family protein	-
DE8555_RS13830	1383538..1384116	+	579	WP_002238083.1	phage tail protein I	-
DE8555_RS07220	1384157..1386412	+	2256	WP_154021145.1	pyocin knob domain-containing protein	-
DE8555_RS07230	1387038..1387349	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
DE8555_RS07235	1387357..1387635	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DE8555_RS07240	1387720..1388325	+	606	WP_002219301.1	hypothetical protein	-
DE8555_RS07245	1388304..1388600	+	297	WP_002242836.1	hypothetical protein	-
DE8555_RS07250	1388813..1390000	+	1188	WP_061375318.1	phage tail sheath subtilisin-like domain-containing protein	-
DE8555_RS07255	1390043..1390549	+	507	WP_014575332.1	phage major tail tube protein	-
DE8555_RS07260	1390596..1390955	+	360	WP_002238090.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1363135..1433101	69966

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T56416 WP_002242826.1 NZ_CP012393:c1387635-1387357 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T56416 NZ_CP012393:c1387635-1387357 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCTGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT56416 WP_002221020.1 NZ_CP012393:c1387349-1387038 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT56416 NZ_CP012393:c1387349-1387038 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6