Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2429682..2430196 Replicon chromosome
Accession NZ_CP012382
Organism Streptomyces ambofaciens ATCC 23877

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2AQU7
Locus tag SAM23877_RS10930 Protein ID WP_053129813.1
Coordinates 2429942..2430196 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2ARB6
Locus tag SAM23877_RS10925 Protein ID WP_053129810.1
Coordinates 2429682..2429945 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAM23877_RS10915 2425390..2426250 + 861 WP_053129796.1 phosphatase PAP2 family protein -
SAM23877_RS10920 2426520..2429528 - 3009 WP_053129807.1 bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase -
SAM23877_RS10925 2429682..2429945 + 264 WP_053129810.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SAM23877_RS10930 2429942..2430196 + 255 WP_053129813.1 Txe/YoeB family addiction module toxin Toxin
SAM23877_RS10935 2430257..2430703 + 447 WP_053129816.1 VOC family protein -
SAM23877_RS10940 2430730..2432484 - 1755 WP_053129819.1 NAD+ synthase -
SAM23877_RS10945 2432539..2433165 - 627 WP_053129822.1 DUF305 domain-containing protein -
SAM23877_RS10950 2433162..2433833 - 672 WP_053129825.1 DUF3105 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9999.29 Da        Isoelectric Point: 9.3758

>T56413 WP_053129813.1 NZ_CP012382:2429942-2430196 [Streptomyces ambofaciens ATCC 23877]
VRIAFTSHGWEDYVHWAESDRKVTRRINKLITDISRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPTDDELIIVQA
RYHY

Download         Length: 255 bp

>T56413 NZ_CP012382:2429942-2430196 [Streptomyces ambofaciens ATCC 23877]
GTGAGAATCGCTTTCACGTCGCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGGTCACCAGACGGAT
CAACAAGCTGATCACCGACATCTCCCGCGACCCGTTCAAGGGCATCGGCAAGCCGGAGCCGCTGAAGGGCGACCTGTCGG
GCTACTGGTCACGCCGCATCGACGACACGCACCGTCTGGTCTACAAGCCCACCGACGACGAGCTGATCATCGTCCAGGCG
CGGTACCACTACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9707.84 Da        Isoelectric Point: 5.1312

>AT56413 WP_053129810.1 NZ_CP012382:2429682-2429945 [Streptomyces ambofaciens ATCC 23877]
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPKNARRLLDSIAEAEAGGARRRDLI
DPDAERA

Download         Length: 264 bp

>AT56413 NZ_CP012382:2429682-2429945 [Streptomyces ambofaciens ATCC 23877]
ATGTCCATTACCGCCAGCGAAGCCCGTCAGAACCTGTTCCCGCTGATAGAGCAGGTCAACGAGGATCACGCCCCGGTGCA
CATCACCTCCCGCAAGGGAAACGCCGTGCTCATGTCGGAGGAGGACTTCACCGCCTGGACGGAGACGGTGCATCTGCTGC
GGTCGCCCAAGAACGCCCGCCGTCTGCTCGACTCGATCGCGGAGGCCGAGGCCGGCGGTGCGCGGCGGCGCGACCTGATC
GACCCGGACGCGGAGCGGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2AQU7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2ARB6

References