Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 3289892..3290411 Replicon chromosome
Accession NZ_CP012375
Organism Microcystis aeruginosa NIES-2481

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0F6U6Y9
Locus tag amyaer_RS16215 Protein ID WP_046662850.1
Coordinates 3289892..3290158 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID I4GT15
Locus tag amyaer_RS16220 Protein ID WP_002783395.1
Coordinates 3290151..3290411 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
amyaer_RS16160 3284995..3285258 - 264 WP_046663814.1 HigA family addiction module antidote protein -
amyaer_RS16165 3285488..3285724 + 237 WP_008202209.1 hypothetical protein -
amyaer_RS16170 3285724..3286176 + 453 WP_002750618.1 PIN domain-containing protein -
amyaer_RS16175 3286337..3286588 - 252 WP_004162266.1 hypothetical protein -
amyaer_RS16180 3286581..3286826 - 246 WP_002734321.1 hypothetical protein -
amyaer_RS16185 3287168..3287884 + 717 WP_046662848.1 PEP-CTERM sorting domain-containing protein -
amyaer_RS16190 3288048..3288302 + 255 WP_002734916.1 hypothetical protein -
amyaer_RS16195 3288303..3288638 + 336 WP_002768260.1 type II toxin-antitoxin system PemK/MazF family toxin -
amyaer_RS16205 3288993..3289286 + 294 WP_002783391.1 nucleotidyltransferase family protein -
amyaer_RS16210 3289283..3289627 + 345 WP_046662849.1 DUF86 domain-containing protein -
amyaer_RS16215 3289892..3290158 - 267 WP_046662850.1 Txe/YoeB family addiction module toxin Toxin
amyaer_RS16220 3290151..3290411 - 261 WP_002783395.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
amyaer_RS16230 3290778..3291815 - 1038 WP_046662851.1 fatty acid desaturase -
amyaer_RS16235 3292122..3293285 - 1164 WP_066030036.1 pyridoxal phosphate-dependent aminotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10473.06 Da        Isoelectric Point: 9.8354

>T56329 WP_046662850.1 NZ_CP012375:c3290158-3289892 [Microcystis aeruginosa NIES-2481]
MDNWQLFFTKQAKKDAEKLARTGLAKQANELLNILKSNPYQSYPVYEKLSGDLASYYSRRINIQHRLVDQVIPEEKVVKI
IRMWTHYE

Download         Length: 267 bp

>T56329 NZ_CP012375:c3290158-3289892 [Microcystis aeruginosa NIES-2481]
ATGGATAATTGGCAGTTGTTTTTTACCAAACAAGCGAAAAAAGATGCTGAAAAGCTGGCTCGTACTGGGTTGGCAAAACA
AGCTAACGAGTTATTAAATATTCTTAAGTCAAATCCCTATCAATCTTATCCTGTTTATGAGAAACTCAGTGGTGATTTAG
CGAGCTATTATTCTAGACGTATTAATATTCAGCATCGTTTGGTTGATCAGGTTATTCCAGAAGAGAAGGTTGTCAAAATT
ATACGGATGTGGACTCATTATGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.59 Da        Isoelectric Point: 3.8305

>AT56329 WP_002783395.1 NZ_CP012375:c3290411-3290151 [Microcystis aeruginosa NIES-2481]
MKIVTVTEAKEQIDELVNDTNDNHQPILLSGTKKNAILIAEEDWNSIQETLYLYSIPGMVDSIIEGGNTSIEDCLDEAGI
RAILNG

Download         Length: 261 bp

>AT56329 NZ_CP012375:c3290411-3290151 [Microcystis aeruginosa NIES-2481]
ATGAAAATTGTTACTGTTACTGAGGCCAAAGAACAAATTGATGAATTAGTGAATGATACCAATGATAATCATCAACCGAT
TTTGTTATCTGGTACGAAAAAGAATGCTATTTTAATTGCTGAGGAAGATTGGAACTCTATTCAAGAAACGCTTTATTTGT
ATTCTATTCCTGGTATGGTAGATTCAATTATTGAAGGTGGCAACACTTCTATTGAAGATTGTCTGGATGAGGCGGGTATC
AGAGCAATTTTAAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6U6Y9

Antitoxin

Source ID Structure
AlphaFold DB I4GT15

References