Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 37463..38082 Replicon chromosome
Accession NZ_CP012373
Organism Beggiatoa leptomitoformis strain D-402

Toxin (Protein)


Gene name higB Uniprot ID A0A2N9YCT0
Locus tag AL038_RS00230 Protein ID WP_062147296.1
Coordinates 37765..38082 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2N9YCU8
Locus tag AL038_RS00225 Protein ID WP_062147293.1
Coordinates 37463..37768 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL038_RS00205 34372..34710 + 339 WP_062147283.1 DUF5455 family protein -
AL038_RS00210 34714..35961 + 1248 WP_062147285.1 hypothetical protein -
AL038_RS00215 36156..36428 + 273 WP_062147288.1 hypothetical protein -
AL038_RS00220 36388..36882 - 495 WP_062147290.1 hypothetical protein -
AL038_RS00225 37463..37768 - 306 WP_062147293.1 helix-turn-helix domain-containing protein Antitoxin
AL038_RS00230 37765..38082 - 318 WP_062147296.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL038_RS00235 38151..38495 - 345 WP_062147299.1 tyrosine-type recombinase/integrase -
AL038_RS18205 39238..39330 + 93 WP_201800149.1 type II toxin-antitoxin system HicA family toxin -
AL038_RS00250 39503..40528 + 1026 WP_062147302.1 restriction endonuclease -
AL038_RS00255 40544..42385 + 1842 WP_062147305.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(30-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12168.21 Da        Isoelectric Point: 9.3251

>T56321 WP_062147296.1 NZ_CP012373:c38082-37765 [Beggiatoa leptomitoformis]
MVIIEPPIFTKLIKALMSDDEYKDLQEALINRPERGVLIKNSGGLRKIRWALEGRGKSGGVRIIYYWMSQDNQLYMLLVY
PKNEQDNLTDAQIASLKQIVEKWSL

Download         Length: 318 bp

>T56321 NZ_CP012373:c38082-37765 [Beggiatoa leptomitoformis]
ATGGTAATTATAGAACCCCCCATTTTTACGAAACTTATTAAAGCATTAATGAGCGATGATGAATATAAGGACTTGCAAGA
GGCTTTAATCAACCGCCCAGAGAGAGGTGTTTTAATTAAAAATAGTGGTGGACTTAGAAAAATACGTTGGGCGTTAGAAG
GACGTGGTAAAAGTGGCGGTGTAAGGATTATCTATTACTGGATGTCTCAAGATAACCAATTGTATATGTTACTTGTTTAT
CCTAAAAATGAACAAGATAACTTAACCGATGCACAAATAGCCTCACTGAAGCAAATTGTAGAGAAGTGGTCATTATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11313.97 Da        Isoelectric Point: 10.3102

>AT56321 WP_062147293.1 NZ_CP012373:c37768-37463 [Beggiatoa leptomitoformis]
MKDELFNQLMESVTQADEIIQGKMNSQQVTNFEEPIVKAIRAKTGLTQSRFADAIGVSKRTLENWEQGRRHPTGSARALL
RILEADPKSVALLKSQFLSKA

Download         Length: 306 bp

>AT56321 NZ_CP012373:c37768-37463 [Beggiatoa leptomitoformis]
ATGAAAGATGAATTATTTAACCAATTGATGGAAAGCGTCACCCAAGCGGATGAGATTATTCAAGGCAAAATGAATTCGCA
ACAGGTAACTAATTTTGAAGAACCCATCGTGAAAGCGATTCGTGCTAAAACGGGGCTAACTCAAAGTCGTTTTGCTGATG
CGATAGGCGTAAGCAAACGTACTTTGGAAAATTGGGAGCAAGGTCGTCGACATCCAACAGGTTCAGCACGTGCGTTATTA
AGAATTCTTGAGGCTGACCCTAAAAGTGTTGCTCTCTTAAAAAGCCAGTTTTTATCAAAAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N9YCT0

Antitoxin

Source ID Structure
AlphaFold DB A0A2N9YCU8

References