Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 108591..109126 | Replicon | plasmid unnamed 1 |
| Accession | NZ_CP012367 | ||
| Organism | Enterococcus durans strain KLDS 6.0933 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | R2PQC0 |
| Locus tag | LIANG_RS14130 | Protein ID | WP_002314366.1 |
| Coordinates | 108591..108863 (-) | Length | 91 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | Q3Y220 |
| Locus tag | LIANG_RS14135 | Protein ID | WP_002297422.1 |
| Coordinates | 108863..109126 (-) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LIANG_RS14095 (LIANG_14115) | 103843..104046 | - | 204 | WP_192845893.1 | leucocin A/sakacin P family class II bacteriocin | - |
| LIANG_RS14100 (LIANG_14120) | 104373..105053 | - | 681 | Protein_113 | IS6 family transposase | - |
| LIANG_RS16070 | 105090..105218 | - | 129 | WP_229205526.1 | hypothetical protein | - |
| LIANG_RS14105 (LIANG_14125) | 105230..105895 | - | 666 | WP_239520004.1 | S8 family serine peptidase | - |
| LIANG_RS14110 (LIANG_14130) | 106218..106765 | - | 548 | Protein_116 | hypothetical protein | - |
| LIANG_RS14115 (LIANG_14135) | 106766..107623 | - | 858 | WP_002292680.1 | ParA family protein | - |
| LIANG_RS14120 (LIANG_14140) | 107908..108195 | - | 288 | WP_016177565.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| LIANG_RS14125 (LIANG_14145) | 108185..108514 | - | 330 | WP_002292678.1 | AbrB family transcriptional regulator | - |
| LIANG_RS14130 (LIANG_14150) | 108591..108863 | - | 273 | WP_002314366.1 | Txe/YoeB family addiction module toxin | Toxin |
| LIANG_RS14135 (LIANG_14155) | 108863..109126 | - | 264 | WP_002297422.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LIANG_RS14140 (LIANG_14160) | 109232..110158 | - | 927 | WP_002328829.1 | hypothetical protein | - |
| LIANG_RS14145 (LIANG_14165) | 110809..111489 | - | 681 | WP_053109498.1 | IS6-like element IS1216 family transposase | - |
| LIANG_RS16075 | 111640..111789 | + | 150 | WP_016853412.1 | hypothetical protein | - |
| LIANG_RS14150 (LIANG_14170) | 111822..112505 | + | 684 | WP_053109496.1 | response regulator transcription factor | - |
| LIANG_RS16080 | 112502..113368 | + | 867 | WP_228012596.1 | histidine kinase dimerization/phospho-acceptor domain-containing protein | - |
| LIANG_RS16085 | 113459..113911 | + | 453 | WP_239590664.1 | ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | ClpL | - | 1..163286 | 163286 | |
| - | flank | IS/Tn | - | - | 110809..111489 | 680 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10780.24 Da Isoelectric Point: 9.9724
>T56312 WP_002314366.1 NZ_CP012367:c108863-108591 [Enterococcus durans]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
Download Length: 273 bp
>T56312 NZ_CP012367:c108863-108591 [Enterococcus durans]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9959.22 Da Isoelectric Point: 4.5370
>AT56312 WP_002297422.1 NZ_CP012367:c109126-108863 [Enterococcus durans]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
Download Length: 264 bp
>AT56312 NZ_CP012367:c109126-108863 [Enterococcus durans]
ATGGCAAAAACTGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA
ATGGCAAAAACTGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829F704 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829F006 |