Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1594260..1594859 Replicon chromosome
Accession NZ_CP012331
Organism Alcanivorax xenomutans strain P40

Toxin (Protein)


Gene name higB Uniprot ID A0A154C4Z0
Locus tag P40_RS07575 Protein ID WP_055100556.1
Coordinates 1594260..1594538 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A154C4L0
Locus tag P40_RS07580 Protein ID WP_055100557.1
Coordinates 1594551..1594859 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P40_RS07550 1590634..1592181 - 1548 WP_080530715.1 adenylate cyclase -
P40_RS07555 1592406..1592969 + 564 WP_080530716.1 nitroreductase -
P40_RS07560 1592962..1593420 + 459 WP_080530717.1 YiiD C-terminal domain-containing protein -
P40_RS07565 1593417..1593851 + 435 WP_080530718.1 MAPEG family protein -
P40_RS07575 1594260..1594538 + 279 WP_055100556.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P40_RS07580 1594551..1594859 + 309 WP_055100557.1 HigA family addiction module antidote protein Antitoxin
P40_RS07585 1594885..1595559 - 675 WP_080530719.1 PadR family transcriptional regulator -
P40_RS07590 1595749..1596792 + 1044 WP_167374822.1 DUF2236 domain-containing protein -
P40_RS07595 1596807..1597808 + 1002 WP_145953556.1 hypothetical protein -
P40_RS07600 1597808..1598260 + 453 WP_145953557.1 nuclear transport factor 2 family protein -
P40_RS07605 1598300..1598482 - 183 WP_022994011.1 hypothetical protein -
P40_RS07610 1598589..1598981 - 393 WP_026948935.1 tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-68)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10664.28 Da        Isoelectric Point: 10.0343

>T56299 WP_055100556.1 NZ_CP012331:1594260-1594538 [Alcanivorax xenomutans]
MIKSFCCPDTRSLFETGKTRRWSGIGRVAQRKLAMLHAARELRDLLSPPGNRLEALKGDRLGQHSIRINDQWRICFRWTS
VGPEDVEIVDYH

Download         Length: 279 bp

>T56299 NZ_CP012331:1594260-1594538 [Alcanivorax xenomutans]
ATGATTAAGAGCTTTTGTTGCCCGGACACTCGCAGCTTGTTTGAGACTGGCAAGACCCGCCGTTGGAGCGGGATTGGCAG
AGTGGCTCAACGCAAACTGGCCATGCTGCATGCCGCCAGAGAGCTGCGGGATTTGTTGTCACCGCCGGGTAACAGGTTGG
AGGCGCTTAAAGGAGACCGTTTGGGACAGCACAGCATCCGCATCAATGACCAATGGCGAATCTGTTTCCGTTGGACAAGT
GTCGGGCCGGAGGATGTGGAAATTGTGGATTATCACTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11573.34 Da        Isoelectric Point: 6.8713

>AT56299 WP_055100557.1 NZ_CP012331:1594551-1594859 [Alcanivorax xenomutans]
MIQNGMRPVHPGEVLREEFLEPLGISAHALSRALHVSAPRVNEIVRERRGITADTAMRLARFFNTTPHFWMNLQAEYDIR
VAENMSAKVIAEEVEPYKAACV

Download         Length: 309 bp

>AT56299 NZ_CP012331:1594551-1594859 [Alcanivorax xenomutans]
ATGATTCAGAATGGAATGCGTCCGGTCCATCCGGGCGAAGTATTGCGTGAGGAATTCCTGGAGCCGCTGGGTATCAGCGC
CCATGCTCTATCGCGGGCGCTGCATGTCTCGGCGCCGCGCGTCAATGAGATCGTACGCGAGAGGCGCGGCATTACCGCGG
ATACGGCGATGCGATTGGCCCGCTTTTTCAACACAACGCCGCATTTCTGGATGAACCTGCAAGCGGAGTATGATATTCGT
GTCGCCGAAAACATGTCCGCGAAGGTGATTGCCGAGGAGGTTGAGCCCTACAAAGCGGCTTGCGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A154C4Z0

Antitoxin

Source ID Structure
AlphaFold DB A0A154C4L0

References