Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 389349..389916 Replicon chromosome
Accession NZ_CP012294
Organism Pediococcus damnosus strain TMW 2.1536

Toxin (Protein)


Gene name yafQ Uniprot ID A0A2G9VDT9
Locus tag ADU73_RS01940 Protein ID WP_046872245.1
Coordinates 389611..389916 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A143AMC1
Locus tag ADU73_RS01935 Protein ID WP_046872246.1
Coordinates 389349..389618 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADU73_RS01910 385351..386142 - 792 WP_062913123.1 alpha/beta hydrolase -
ADU73_RS01915 386363..386674 - 312 WP_046872272.1 hypothetical protein -
ADU73_RS01920 386884..387825 - 942 WP_046872249.1 alpha/beta hydrolase -
ADU73_RS01925 388057..388701 - 645 WP_046872248.1 SDR family oxidoreductase -
ADU73_RS01930 388712..389065 - 354 WP_046872247.1 MerR family transcriptional regulator -
ADU73_RS01935 389349..389618 + 270 WP_046872246.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ADU73_RS01940 389611..389916 + 306 WP_046872245.1 type II toxin-antitoxin system YafQ family toxin Toxin
ADU73_RS01945 390100..390948 - 849 WP_046872244.1 aldo/keto reductase -
ADU73_RS01950 391223..391540 + 318 WP_046872243.1 multidrug efflux SMR transporter -
ADU73_RS01955 392054..392731 - 678 WP_046872242.1 Fic family protein -
ADU73_RS10310 392982..394016 - 1035 WP_046872241.1 DUF4767 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(8-99)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-83)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12033.83 Da        Isoelectric Point: 9.3689

>T56239 WP_046872245.1 NZ_CP012294:389611-389916 [Pediococcus damnosus]
MYKANPLPTFRRDVKHLVKKHYPIEDLKHVVDLLLEGTHQDELRLKFDDHQLVSNSAWKGHRELHINKSYNNNWLLIYRI
DKEDLVLELVRSGSHKDLLGK

Download         Length: 306 bp

>T56239 NZ_CP012294:389611-389916 [Pediococcus damnosus]
ATGTATAAAGCAAATCCTTTACCCACATTCAGGCGGGATGTCAAACATCTGGTAAAAAAACACTATCCAATTGAAGATTT
AAAACATGTTGTTGATCTACTTTTAGAAGGTACCCATCAAGATGAACTACGCCTTAAATTTGACGATCATCAGCTGGTAT
CTAACAGTGCATGGAAAGGTCATCGTGAGTTACACATCAATAAAAGCTACAACAATAATTGGTTACTAATTTATCGTATT
GACAAAGAAGACCTAGTTCTCGAATTAGTTCGGTCAGGATCGCATAAAGATTTACTTGGTAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10161.60 Da        Isoelectric Point: 5.7065

>AT56239 WP_046872246.1 NZ_CP012294:389349-389618 [Pediococcus damnosus]
MNTKSKDTRLSIRIEPELKSAGQDVAKDMGMDLTTAVKMFITAMVKEQRLPFEPTSLPVETLQALRESEHHNDYKTYSSA
KEMWSDLNV

Download         Length: 270 bp

>AT56239 NZ_CP012294:389349-389618 [Pediococcus damnosus]
ATGAACACAAAATCTAAAGATACCCGCCTCAGTATTCGTATCGAACCGGAACTTAAATCTGCCGGACAAGATGTTGCAAA
AGATATGGGGATGGATTTAACAACTGCTGTTAAAATGTTTATTACTGCTATGGTCAAAGAACAACGTTTACCTTTTGAAC
CAACCAGTCTTCCGGTAGAAACATTACAAGCTTTACGTGAATCTGAACACCATAATGATTATAAAACCTATAGTAGCGCA
AAAGAAATGTGGTCCGATTTAAATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G9VDT9

Antitoxin

Source ID Structure
AlphaFold DB A0A143AMC1

References