56235

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 368187..368754 Replicon chromosome
Accession NZ_CP012288
Organism Pediococcus damnosus strain TMW 2.1535

Toxin (Protein)


Gene name yafQ Uniprot ID A0A2G9VDT9
Locus tag ADU72_RS01870 Protein ID WP_046872245.1
Coordinates 368449..368754 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A143AMC1
Locus tag ADU72_RS01865 Protein ID WP_046872246.1
Coordinates 368187..368456 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADU72_RS01840 364190..364906 - 717 WP_063510361.1 alpha/beta hydrolase -
ADU72_RS01845 365201..365512 - 312 WP_046872272.1 hypothetical protein -
ADU72_RS01850 365722..366663 - 942 WP_046872249.1 alpha/beta hydrolase -
ADU72_RS01855 366895..367539 - 645 WP_046872248.1 SDR family oxidoreductase -
ADU72_RS01860 367550..367903 - 354 WP_046872247.1 MerR family transcriptional regulator -
ADU72_RS01865 368187..368456 + 270 WP_046872246.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ADU72_RS01870 368449..368754 + 306 WP_046872245.1 type II toxin-antitoxin system YafQ family toxin Toxin
ADU72_RS01875 368939..369787 - 849 WP_046872244.1 aldo/keto reductase -
ADU72_RS01880 370062..370379 + 318 WP_046872243.1 multidrug efflux SMR transporter -
ADU72_RS01885 371045..372250 + 1206 WP_062904288.1 IS110 family transposase -
ADU72_RS01890 372540..373217 - 678 WP_046872242.1 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(8-99)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-83)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12033.83 Da        Isoelectric Point: 9.3689

>T56235 WP_046872245.1 NZ_CP012288:368449-368754 [Pediococcus damnosus]
MYKANPLPTFRRDVKHLVKKHYPIEDLKHVVDLLLEGTHQDELRLKFDDHQLVSNSAWKGHRELHINKSYNNNWLLIYRI
DKEDLVLELVRSGSHKDLLGK

Download         Length: 306 bp

>T56235 NZ_CP012288:368449-368754 [Pediococcus damnosus]
ATGTATAAAGCAAATCCTTTACCCACATTCAGGCGGGATGTCAAACATCTGGTAAAAAAACACTATCCAATTGAAGATTT
AAAACATGTTGTTGATCTACTTTTAGAAGGTACCCATCAAGATGAACTACGCCTTAAATTTGACGATCATCAGCTGGTAT
CTAACAGTGCATGGAAAGGTCATCGTGAGTTACACATCAATAAAAGCTACAACAATAATTGGTTACTAATTTATCGTATT
GACAAAGAAGACCTAGTTCTCGAATTAGTTCGGTCAGGATCGCATAAAGATTTACTTGGTAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10161.60 Da        Isoelectric Point: 5.7065

>AT56235 WP_046872246.1 NZ_CP012288:368187-368456 [Pediococcus damnosus]
MNTKSKDTRLSIRIEPELKSAGQDVAKDMGMDLTTAVKMFITAMVKEQRLPFEPTSLPVETLQALRESEHHNDYKTYSSA
KEMWSDLNV

Download         Length: 270 bp

>AT56235 NZ_CP012288:368187-368456 [Pediococcus damnosus]
ATGAACACAAAATCTAAAGATACCCGCCTCAGTATTCGTATCGAACCGGAACTTAAATCTGCCGGACAAGATGTTGCAAA
AGATATGGGGATGGATTTAACAACTGCTGTTAAAATGTTTATTACTGCTATGGTCAAAGAACAACGTTTACCTTTTGAAC
CAACCAGTCTTCCGGTAGAAACATTACAAGCTTTACGTGAATCTGAACACCATAATGATTATAAAACCTATAGTAGCGCA
AAAGAAATGTGGTCCGATTTAAATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G9VDT9

Antitoxin

Source ID Structure
AlphaFold DB A0A143AMC1

References