Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1518273..1518840 Replicon chromosome
Accession NZ_CP012283
Organism Pediococcus damnosus strain TMW 2.1534

Toxin (Protein)


Gene name yafQ Uniprot ID A0A2G9VDT9
Locus tag ADU71_RS07185 Protein ID WP_046872245.1
Coordinates 1518273..1518578 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A143AMC1
Locus tag ADU71_RS07190 Protein ID WP_046872246.1
Coordinates 1518571..1518840 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADU71_RS11140 1514172..1515206 + 1035 WP_081212613.1 DUF4767 domain-containing protein -
ADU71_RS07170 1515457..1516134 + 678 WP_046872242.1 Fic family protein -
ADU71_RS07175 1516648..1516965 - 318 WP_046872243.1 multidrug efflux SMR transporter -
ADU71_RS07180 1517240..1518088 + 849 WP_062909691.1 aldo/keto reductase -
ADU71_RS07185 1518273..1518578 - 306 WP_046872245.1 type II toxin-antitoxin system YafQ family toxin Toxin
ADU71_RS07190 1518571..1518840 - 270 WP_046872246.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ADU71_RS07195 1519124..1519477 + 354 WP_046872247.1 MerR family transcriptional regulator -
ADU71_RS07200 1519488..1520132 + 645 WP_062904103.1 SDR family oxidoreductase -
ADU71_RS07205 1520364..1521305 + 942 WP_046872249.1 alpha/beta hydrolase -
ADU71_RS07210 1521515..1521826 + 312 WP_046872272.1 hypothetical protein -
ADU71_RS07215 1522047..1522838 + 792 WP_046872250.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(8-99)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-83)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12033.83 Da        Isoelectric Point: 9.3689

>T56233 WP_046872245.1 NZ_CP012283:c1518578-1518273 [Pediococcus damnosus]
MYKANPLPTFRRDVKHLVKKHYPIEDLKHVVDLLLEGTHQDELRLKFDDHQLVSNSAWKGHRELHINKSYNNNWLLIYRI
DKEDLVLELVRSGSHKDLLGK

Download         Length: 306 bp

>T56233 NZ_CP012283:c1518578-1518273 [Pediococcus damnosus]
ATGTATAAAGCAAATCCTTTACCCACATTCAGGCGGGATGTCAAACATCTGGTAAAAAAACACTATCCAATTGAAGATTT
AAAACATGTTGTTGATCTACTTTTAGAAGGTACCCATCAAGATGAACTACGCCTTAAATTTGACGATCATCAGCTGGTAT
CTAACAGTGCATGGAAAGGTCATCGTGAGTTACACATCAATAAAAGCTACAACAATAATTGGTTACTAATTTATCGTATT
GACAAAGAAGACCTAGTTCTCGAATTAGTTCGGTCAGGATCGCACAAAGATTTACTTGGTAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10161.60 Da        Isoelectric Point: 5.7065

>AT56233 WP_046872246.1 NZ_CP012283:c1518840-1518571 [Pediococcus damnosus]
MNTKSKDTRLSIRIEPELKSAGQDVAKDMGMDLTTAVKMFITAMVKEQRLPFEPTSLPVETLQALRESEHHNDYKTYSSA
KEMWSDLNV

Download         Length: 270 bp

>AT56233 NZ_CP012283:c1518840-1518571 [Pediococcus damnosus]
ATGAACACAAAATCTAAAGATACCCGCCTCAGTATTCGTATCGAACCGGAACTTAAATCTGCCGGACAAGATGTTGCAAA
AGATATGGGGATGGATTTAACAACTGCTGTTAAAATGTTTATTACTGCTATGGTCAAAGAACAACGTTTACCTTTTGAAC
CAACCAGTCTTCCGGTAGAAACATTACAAGCTTTACGTGAATCTGAACACCATAATGATTATAAAACCTATAGTAGCGCA
AAAGAAATGTGGTCCGATTTAAATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G9VDT9

Antitoxin

Source ID Structure
AlphaFold DB A0A143AMC1

References