Detailed information of TA system TA056211

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1153828..1154476
• Replicon: chromosome
• Accession: NZ_CP012268
• Organism: Cronobacter muytjensii ATCC 51329

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AFK63_RS05295
• Protein ID: WP_038861909.1
• Coordinates: 1153828..1154193 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AFK63_RS05300
• Protein ID: WP_038861911.1
• Coordinates: 1154180..1154476 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AFK63_RS05285	1149234..1152356	-	3123	WP_038861904.1	MdtB/MuxB family multidrug efflux RND transporter permease subunit	-
AFK63_RS05290	1152356..1153597	-	1242	WP_038861906.1	MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit	-
AFK63_RS05295	1153828..1154193	+	366	WP_038861909.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AFK63_RS05300	1154180..1154476	+	297	WP_038861911.1	XRE family transcriptional regulator	Antitoxin
AFK63_RS05305	1154482..1155834	-	1353	WP_038861914.1	molecular chaperone	-
AFK63_RS05310	1155971..1156819	+	849	WP_038861915.1	DNA-3-methyladenine glycosylase 2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-86)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14110.16 Da
• Isoelectric Point: 9.8187

>T56211 WP_038861909.1 NZ_CP012268:1153828-1154193 [Cronobacter muytjensii ATCC 51329]
MTWTVIFTPHFYEWYQQQPEGLQDRIAALLWNLRHSGPLVGRPLVDTIKGSRIANLKELRVQYGGSPWRVFFAFDPTRQA
VVLCAGNKRGHKDFYKTLITQAETAFFQHLQKIMESKNEND

Nucleotide

• Length: 366 bp

>T56211 NZ_CP012268:1153828-1154193 [Cronobacter muytjensii ATCC 51329]
ATGACATGGACGGTGATTTTTACCCCGCATTTTTATGAGTGGTATCAACAACAGCCCGAAGGATTACAGGATCGTATCGC
CGCGCTGTTATGGAATTTACGCCACAGCGGCCCGTTGGTTGGGCGTCCGCTGGTGGACACGATAAAAGGCTCGCGGATCG
CCAATCTTAAAGAGCTGCGCGTTCAGTATGGCGGTTCGCCGTGGCGGGTATTTTTTGCCTTCGACCCAACCCGTCAGGCT
GTGGTGCTGTGTGCAGGCAACAAGCGCGGTCACAAAGATTTTTATAAAACCTTAATCACGCAGGCGGAGACGGCGTTCTT
CCAGCATCTGCAAAAAATAATGGAGAGTAAAAATGAAAACGATTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10991.91 Da
• Isoelectric Point: 5.2290

>AT56211 WP_038861911.1 NZ_CP012268:1154180-1154476 [Cronobacter muytjensii ATCC 51329]
MKTIDDVMAEFPPERQAEILRMADEIALEHGLPRLREERAFSQQRLAEIMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLVELPEGSKVIPV

Nucleotide

• Length: 297 bp

>AT56211 NZ_CP012268:1154180-1154476 [Cronobacter muytjensii ATCC 51329]
ATGAAAACGATTGATGATGTGATGGCGGAGTTTCCGCCAGAGCGGCAAGCTGAGATCCTGCGCATGGCTGATGAAATCGC
GCTTGAACACGGGCTGCCGCGCCTTCGCGAAGAAAGGGCGTTCTCGCAGCAGCGGCTGGCGGAGATAATGGGCGTTACGC
AGCCCGCTATCGCCGCCATCGAACAGCGCGGAAAGGAGATCAAACTGCTGACGCTCAAGCGCTATGTCGAAGCGCTGGGC
GGGAAGCTGTCCCTGCTGGTTGAGCTGCCCGAAGGCAGCAAAGTCATTCCTGTTTAA