Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 13468..14195 | Replicon | plasmid pCUNV1 |
| Accession | NZ_CP012258 | ||
| Organism | Cronobacter universalis NCTC 9529 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A376KPM7 |
| Locus tag | AFK65_RS20030 | Protein ID | WP_007705726.1 |
| Coordinates | 13884..14195 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A376KTT2 |
| Locus tag | AFK65_RS20025 | Protein ID | WP_007705727.1 |
| Coordinates | 13468..13887 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AFK65_RS19995 | 8567..9874 | - | 1308 | WP_007705757.1 | MFS transporter | - |
| AFK65_RS20000 | 10173..10730 | - | 558 | WP_032805867.1 | TetR/AcrR family transcriptional regulator | - |
| AFK65_RS20005 | 10831..11742 | + | 912 | WP_038858852.1 | ABC transporter six-transmembrane domain-containing protein | - |
| AFK65_RS20010 | 11781..12269 | - | 489 | WP_038858853.1 | DinB family protein | - |
| AFK65_RS20015 | 12420..12863 | + | 444 | WP_007705731.1 | NUDIX domain-containing protein | - |
| AFK65_RS20020 | 12945..13301 | + | 357 | WP_032805180.1 | nuclear transport factor 2 family protein | - |
| AFK65_RS20025 | 13468..13887 | - | 420 | WP_007705727.1 | helix-turn-helix domain-containing protein | Antitoxin |
| AFK65_RS20030 | 13884..14195 | - | 312 | WP_007705726.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| AFK65_RS20035 | 14599..15489 | + | 891 | WP_007705725.1 | transcriptional regulator | - |
| AFK65_RS20040 | 15544..15927 | - | 384 | WP_007705724.1 | hypothetical protein | - |
| AFK65_RS20045 | 15984..16679 | - | 696 | WP_032805179.1 | YafY family transcriptional regulator | - |
| AFK65_RS20050 | 16763..17305 | - | 543 | WP_007705721.1 | hypothetical protein | - |
| AFK65_RS20055 | 17433..18371 | - | 939 | WP_007705717.1 | omptin family outer membrane protease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | pla / iutA / iucC / iucB / iucA / mgtB | 1..129777 | 129777 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12227.00 Da Isoelectric Point: 9.6248
>T56179 WP_007705726.1 NZ_CP012258:c14195-13884 [Cronobacter universalis NCTC 9529]
MHVISKEPFEQAARLFPNDATAIKALFRLVCETDFKSPDELRAAVPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHAEYDKLTRYYRENKE
MHVISKEPFEQAARLFPNDATAIKALFRLVCETDFKSPDELRAAVPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHAEYDKLTRYYRENKE
Download Length: 312 bp
>T56179 NZ_CP012258:c14195-13884 [Cronobacter universalis NCTC 9529]
ATGCACGTCATTTCCAAAGAGCCATTTGAACAAGCGGCACGGCTCTTTCCAAACGACGCCACAGCCATAAAGGCGCTGTT
TCGCCTGGTATGCGAAACAGATTTTAAATCGCCTGATGAACTTCGCGCCGCCGTGCCAAGTCTGGACAATTTTAAGTACC
GTAACAAATGGTGGGTGTTAGATGTGGGTGGCAACAACCTGAGGGTTATCGCCTACATCAATTTCGTGAATAAACGCTTC
TACGTGAAGCATATCGCTACCCACGCCGAATACGATAAGCTGACTCGCTACTATCGGGAGAACAAAGAATGA
ATGCACGTCATTTCCAAAGAGCCATTTGAACAAGCGGCACGGCTCTTTCCAAACGACGCCACAGCCATAAAGGCGCTGTT
TCGCCTGGTATGCGAAACAGATTTTAAATCGCCTGATGAACTTCGCGCCGCCGTGCCAAGTCTGGACAATTTTAAGTACC
GTAACAAATGGTGGGTGTTAGATGTGGGTGGCAACAACCTGAGGGTTATCGCCTACATCAATTTCGTGAATAAACGCTTC
TACGTGAAGCATATCGCTACCCACGCCGAATACGATAAGCTGACTCGCTACTATCGGGAGAACAAAGAATGA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15330.50 Da Isoelectric Point: 4.6563
>AT56179 WP_007705727.1 NZ_CP012258:c13887-13468 [Cronobacter universalis NCTC 9529]
MIADTTKAIEATKQLVAAVPLLGGSSSEKDYRDALALVDYLIDHDDENPLIDLLAAKIADYEDNSERFAEFNKEVAEMPV
GVALLRTLIDQHKLSYADLKEEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPQWFL
MIADTTKAIEATKQLVAAVPLLGGSSSEKDYRDALALVDYLIDHDDENPLIDLLAAKIADYEDNSERFAEFNKEVAEMPV
GVALLRTLIDQHKLSYADLKEEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPQWFL
Download Length: 420 bp
>AT56179 NZ_CP012258:c13887-13468 [Cronobacter universalis NCTC 9529]
ATGATCGCCGACACCACTAAAGCTATTGAAGCAACAAAACAACTGGTAGCGGCTGTCCCTCTGCTGGGGGGAAGCTCTTC
TGAGAAGGACTACCGTGACGCGCTGGCGCTGGTGGATTACCTGATTGACCACGACGACGAAAACCCGCTGATCGACTTAC
TGGCAGCCAAAATTGCCGATTACGAAGACAACAGCGAGCGCTTTGCAGAGTTCAACAAAGAAGTTGCAGAAATGCCGGTG
GGCGTCGCGCTGCTGCGCACGCTGATTGACCAGCATAAGCTGTCCTACGCCGATCTGAAGGAAGAAATTGGCTCTAAATC
GCTGGTCAGCCAGATCCTTTCCGGTCAGCGCTCCCTGACGATCTCGCACATTAAGGCACTTTCCGCTCGCTTTGGCGTTA
AGCCGCAATGGTTTCTGTGA
ATGATCGCCGACACCACTAAAGCTATTGAAGCAACAAAACAACTGGTAGCGGCTGTCCCTCTGCTGGGGGGAAGCTCTTC
TGAGAAGGACTACCGTGACGCGCTGGCGCTGGTGGATTACCTGATTGACCACGACGACGAAAACCCGCTGATCGACTTAC
TGGCAGCCAAAATTGCCGATTACGAAGACAACAGCGAGCGCTTTGCAGAGTTCAACAAAGAAGTTGCAGAAATGCCGGTG
GGCGTCGCGCTGCTGCGCACGCTGATTGACCAGCATAAGCTGTCCTACGCCGATCTGAAGGAAGAAATTGGCTCTAAATC
GCTGGTCAGCCAGATCCTTTCCGGTCAGCGCTCCCTGACGATCTCGCACATTAAGGCACTTTCCGCTCGCTTTGGCGTTA
AGCCGCAATGGTTTCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A376KPM7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A376KTT2 |