Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1842556..1843121 Replicon chromosome
Accession NZ_CP012253
Organism Cronobacter sakazakii strain NCTC 8155

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AFK64_RS08695 Protein ID WP_004388463.1
Coordinates 1842556..1842834 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag AFK64_RS08700 Protein ID WP_004388462.1
Coordinates 1842834..1843121 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFK64_RS08680 1837618..1839555 + 1938 WP_015386729.1 HAMP domain-containing protein -
AFK64_RS08685 1839664..1840650 + 987 WP_007888785.1 SDR family oxidoreductase -
AFK64_RS08690 1840652..1842256 - 1605 WP_004388464.1 alpha-amylase family protein -
AFK64_RS08695 1842556..1842834 + 279 WP_004388463.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AFK64_RS08700 1842834..1843121 + 288 WP_004388462.1 HigA family addiction module antidote protein Antitoxin
AFK64_RS08705 1843175..1845292 - 2118 WP_004388461.1 TonB-dependent receptor -
AFK64_RS08710 1845570..1846628 + 1059 WP_004384961.1 YncE family protein -
AFK64_RS08715 1846658..1847524 - 867 WP_004384960.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10559.03 Da        Isoelectric Point: 10.0888

>T56154 WP_004388463.1 NZ_CP012253:1842556-1842834 [Cronobacter sakazakii]
MIRSFRHKGLQRYFETGSTAGIHARHARKISLRLAVLNQAISPADVDLPGFFLHPLTGDRKGIWAVTVSGNWRITFEFRD
GDVFIVNYEDYH

Download         Length: 279 bp

>T56154 NZ_CP012253:1842556-1842834 [Cronobacter sakazakii]
ATGATCAGAAGCTTCAGGCATAAAGGCCTGCAACGCTATTTCGAAACGGGTTCCACCGCAGGCATTCATGCCCGCCATGC
CAGAAAGATTTCTCTGCGGCTGGCGGTGCTGAATCAGGCGATAAGCCCCGCTGACGTCGACTTACCGGGCTTTTTCCTGC
ATCCCCTGACGGGGGATCGTAAAGGTATATGGGCTGTGACCGTCAGCGGAAACTGGCGCATCACGTTTGAGTTTCGGGAT
GGCGATGTCTTTATCGTCAATTATGAGGATTACCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10428.03 Da        Isoelectric Point: 8.7791

>AT56154 WP_004388462.1 NZ_CP012253:1842834-1843121 [Cronobacter sakazakii]
MATMFNPPHPGRLVQESMEALGLSARALAKALDVAPSTVQRLLVGKSDVSPEMALRLSAVLGSSPHVWLGMQNEYDLFQA
RQSVDFSHLQRLQRA

Download         Length: 288 bp

>AT56154 NZ_CP012253:1842834-1843121 [Cronobacter sakazakii]
ATGGCAACGATGTTTAACCCACCGCACCCGGGCAGGCTGGTGCAGGAGTCAATGGAAGCGCTCGGCCTCAGCGCCCGTGC
GCTGGCCAAAGCGCTGGACGTCGCGCCGTCGACGGTGCAGCGGCTGCTGGTCGGCAAATCTGACGTCTCCCCGGAAATGG
CGCTGCGTCTCTCGGCAGTCCTTGGCAGCTCGCCGCATGTCTGGCTGGGTATGCAAAACGAATACGATCTCTTTCAGGCG
CGCCAGTCTGTTGATTTCTCGCACCTGCAACGGTTGCAGAGGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References