Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3733902..3734559 Replicon chromosome
Accession NZ_CP012165
Organism Enterobacter hormaechei subsp. xiangfangensis strain 34978

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LI63_RS19260 Protein ID WP_032609983.1
Coordinates 3733902..3734201 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LI63_RS19265 Protein ID WP_032609984.1
Coordinates 3734212..3734559 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI63_RS19250 3730279..3732471 + 2193 WP_032609980.1 type I secretion system permease/ATPase -
LI63_RS19255 3732491..3733651 + 1161 WP_087920848.1 HlyD family efflux transporter periplasmic adaptor subunit -
LI63_RS19260 3733902..3734201 + 300 WP_032609983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LI63_RS19265 3734212..3734559 + 348 WP_032609984.1 HigA family addiction module antidote protein Antitoxin
LI63_RS19270 3734635..3735816 - 1182 WP_023314694.1 PLP-dependent aminotransferase family protein -
LI63_RS19275 3735837..3736724 - 888 WP_022651703.1 LysR family transcriptional regulator -
LI63_RS19280 3736822..3737424 + 603 WP_022651704.1 short chain dehydrogenase -
LI63_RS19285 3737421..3738152 - 732 WP_022651705.1 class I SAM-dependent methyltransferase -
LI63_RS19290 3738227..3739225 - 999 WP_022651706.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T56071 WP_032609983.1 NZ_CP012165:3733902-3734201 [Enterobacter hormaechei subsp. xiangfangensis]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T56071 NZ_CP012165:3733902-3734201 [Enterobacter hormaechei subsp. xiangfangensis]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TATATGAAGCATTGAGTCCTACGTTGAAGGGATACTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT56071 WP_032609984.1 NZ_CP012165:3734212-3734559 [Enterobacter hormaechei subsp. xiangfangensis]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT56071 NZ_CP012165:3734212-3734559 [Enterobacter hormaechei subsp. xiangfangensis]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGGTGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAACGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCGGACGTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References