Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3641369..3641943 Replicon chromosome
Accession NZ_CP012154
Organism Wenzhouxiangella marina strain KCTC 42284

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag WM2015_RS15330 Protein ID WP_049726884.1
Coordinates 3641665..3641943 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag WM2015_RS15700 Protein ID WP_082169804.1
Coordinates 3641369..3641656 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM2015_RS15300 3636948..3637343 - 396 WP_049726879.1 hypothetical protein -
WM2015_RS15305 3637363..3637788 - 426 WP_211260945.1 hypothetical protein -
WM2015_RS15310 3638009..3638485 - 477 WP_049726880.1 GNAT family N-acetyltransferase -
WM2015_RS16100 3638504..3638641 - 138 WP_169751201.1 hypothetical protein -
WM2015_RS15315 3638697..3639134 - 438 WP_049726881.1 hypothetical protein -
WM2015_RS15320 3639138..3639587 - 450 WP_049726882.1 GTP pyrophosphokinase -
WM2015_RS15325 3639809..3640375 - 567 WP_049726883.1 hypothetical protein -
WM2015_RS15700 3641369..3641656 - 288 WP_082169804.1 HigA family addiction module antidote protein Antitoxin
WM2015_RS15330 3641665..3641943 - 279 WP_049726884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WM2015_RS15990 3642059..3642700 - 642 WP_156201302.1 hypothetical protein -
WM2015_RS15335 3642885..3643925 + 1041 WP_049724903.1 IS110 family transposase -
WM2015_RS15340 3644194..3644751 - 558 WP_049726885.1 hypothetical protein -
WM2015_RS15995 3645715..3646248 - 534 WP_156201304.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3639809..3650643 10834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10665.17 Da        Isoelectric Point: 10.0860

>T56043 WP_049726884.1 NZ_CP012154:c3641943-3641665 [Wenzhouxiangella marina]
MIRSFRHKGLRRFFESGKTSGIQAQHAIRLRLILGRLHAARQPIDMDLPGLRLHELKGDRIGTYAVNVSGNWRITFQFSG
EDVEVVDYEDYH

Download         Length: 279 bp

>T56043 NZ_CP012154:c3641943-3641665 [Wenzhouxiangella marina]
ATGATAAGGAGCTTCAGGCATAAGGGCCTCCGCCGGTTTTTCGAGTCCGGGAAGACCTCAGGAATCCAGGCTCAGCATGC
CATAAGGCTTCGCCTCATATTGGGACGCCTGCATGCTGCCCGTCAGCCCATAGATATGGATTTGCCGGGGTTAAGGCTCC
ACGAGCTGAAAGGTGATCGAATCGGGACCTACGCTGTCAACGTAAGCGGTAACTGGCGGATTACTTTTCAATTTTCGGGT
GAAGACGTCGAGGTTGTCGACTATGAAGACTATCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10470.05 Da        Isoelectric Point: 6.8696

>AT56043 WP_082169804.1 NZ_CP012154:c3641656-3641369 [Wenzhouxiangella marina]
MLMHNPPHPGEIIRELCIEPLGLSITEAADALGVSRKTLSAILNGRAGISPEMAIRLSIAFNTSSESWLNQQSQFDLWNA
EKHRAELHVKRLVAA

Download         Length: 288 bp

>AT56043 NZ_CP012154:c3641656-3641369 [Wenzhouxiangella marina]
ATGCTGATGCATAACCCCCCGCATCCGGGTGAAATTATCCGGGAGCTTTGTATAGAGCCATTGGGGCTGTCTATCACCGA
GGCAGCAGATGCCTTGGGCGTGAGCAGAAAAACCCTCAGCGCAATATTGAACGGTCGGGCTGGTATTAGCCCCGAAATGG
CCATTCGATTGTCAATTGCGTTTAACACTTCTTCTGAGAGCTGGCTTAATCAGCAGAGTCAGTTCGATCTATGGAACGCT
GAAAAGCATCGTGCGGAACTGCACGTCAAGCGACTTGTTGCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References