Detailed information of TA system TA056011

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1849870..1850095
• Replicon: chromosome
• Accession: NZ_CP012140
• Organism: Shigella flexneri 4c strain 1205

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: AD871_RS10335
• Protein ID: WP_000813254.1
• Coordinates: 1849870..1850025 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1850037..1850095 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AD871_RS10290	1845013..1845495	-	483	WP_000068107.1	ORF6N domain-containing protein	-
AD871_RS10295	1845566..1846705	-	1140	WP_000088354.1	IS3 family transposase	-
AD871_RS10300	1846767..1846940	-	174	WP_000504450.1	hypothetical protein	-
AD871_RS10305	1847093..1847647	-	555	WP_000640143.1	DUF1133 family protein	-
AD871_RS10310	1847644..1847934	-	291	WP_000228038.1	DUF1364 domain-containing protein	-
AD871_RS10315	1847934..1848533	-	600	WP_000940329.1	DUF1367 family protein	-
AD871_RS28825	1848667..1849364	+	698	WP_227804315.1	IS1 family transposase	-
AD871_RS10335	1849870..1850025	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1850037..1850095	+	59	-	-	Antitoxin
AD871_RS10345	1850480..1850845	-	366	WP_000610655.1	DUF551 domain-containing protein	-
AD871_RS10350	1850845..1851510	-	666	WP_000208062.1	hypothetical protein	-
AD871_RS10355	1851507..1851872	-	366	WP_001229297.1	HNH endonuclease signature motif containing protein	-
AD871_RS10360	1851874..1852092	-	219	WP_000256998.1	DUF4014 family protein	-
AD871_RS10365	1852185..1852541	-	357	WP_005048249.1	hypothetical protein	-
AD871_RS10370	1852599..1853021	-	423	WP_001118168.1	DUF977 family protein	-
AD871_RS10375	1853036..1853782	-	747	WP_000788996.1	ATP-binding protein	-
AD871_RS30500	1853928..1854097	-	170	Protein_1883	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	sitABCD	ipaH9.8	1796158..1858012	61854

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T56011 WP_000813254.1 NZ_CP012140:c1850025-1849870 [Shigella flexneri 4c]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T56011 NZ_CP012140:c1850025-1849870 [Shigella flexneri 4c]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT56011 NZ_CP012140:1850037-1850095 [Shigella flexneri 4c]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin