Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1172250..1172475 Replicon chromosome
Accession NZ_CP012140
Organism Shigella flexneri 4c strain 1205

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag AD871_RS06310 Protein ID WP_000813254.1
Coordinates 1172320..1172475 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 1172250..1172308 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AD871_RS06270 1167427..1168689 - 1263 Protein_1140 tyrosine-type recombinase/integrase -
AD871_RS06280 1169027..1169824 - 798 WP_001325918.1 DgsA anti-repressor MtfA -
AD871_RS06290 1170035..1171085 - 1051 Protein_1142 tyrosine-type recombinase/integrase -
AD871_RS06295 1171085..1171225 - 141 Protein_1143 DUF4224 domain-containing protein -
AD871_RS06300 1171252..1171668 + 417 WP_005069274.1 hypothetical protein -
- 1172250..1172308 - 59 - - Antitoxin
AD871_RS06310 1172320..1172475 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
AD871_RS06320 1172643..1172921 + 279 WP_011069426.1 hypothetical protein -
AD871_RS06325 1172923..1173981 + 1059 WP_001265248.1 DUF968 domain-containing protein -
AD871_RS06330 1173982..1174347 + 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
AD871_RS06335 1174344..1175032 + 689 Protein_1149 bacteriophage antitermination protein Q -
AD871_RS06360 1175828..1176043 + 216 WP_000839572.1 class II holin family protein -
AD871_RS06365 1176142..1176816 + 675 WP_004967157.1 IS66-like element accessory protein TnpA -
AD871_RS06370 1176813..1177163 + 351 WP_005049241.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 1133896..1205102 71206


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T56000 WP_000813254.1 NZ_CP012140:1172320-1172475 [Shigella flexneri 4c]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T56000 NZ_CP012140:1172320-1172475 [Shigella flexneri 4c]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT56000 NZ_CP012140:c1172308-1172250 [Shigella flexneri 4c]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References