Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2111395..2111620 Replicon chromosome
Accession NZ_CP012137
Organism Shigella flexneri 2a strain 981

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag AD867_RS11730 Protein ID WP_000813254.1
Coordinates 2111395..2111550 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2111562..2111620 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AD867_RS11675 2106707..2107057 - 351 WP_005049241.1 IS66 family insertion sequence element accessory protein TnpB -
AD867_RS11680 2107054..2107728 - 675 WP_004967157.1 IS66-like element accessory protein TnpA -
AD867_RS11685 2107827..2108042 - 216 WP_000839572.1 class II holin family protein -
AD867_RS11710 2108838..2109526 - 689 Protein_2145 bacteriophage antitermination protein Q -
AD867_RS11715 2109523..2109888 - 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
AD867_RS11720 2109889..2110947 - 1059 WP_001265248.1 DUF968 domain-containing protein -
AD867_RS27835 2110949..2111227 - 279 WP_011069426.1 hypothetical protein -
AD867_RS11730 2111395..2111550 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
- 2111562..2111620 + 59 - - Antitoxin
AD867_RS11740 2112201..2112617 - 417 WP_005069274.1 hypothetical protein -
AD867_RS11745 2112644..2112784 + 141 Protein_2151 DUF4224 domain-containing protein -
AD867_RS11750 2112784..2113834 + 1051 Protein_2152 tyrosine-type recombinase/integrase -
AD867_RS11760 2114045..2114842 + 798 WP_001325918.1 DgsA anti-repressor MtfA -
AD867_RS11770 2115180..2116442 + 1263 Protein_2154 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 2093218..2149971 56753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T55984 WP_000813254.1 NZ_CP012137:c2111550-2111395 [Shigella flexneri 2a]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T55984 NZ_CP012137:c2111550-2111395 [Shigella flexneri 2a]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT55984 NZ_CP012137:2111562-2111620 [Shigella flexneri 2a]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References