55893

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2073017..2073519 Replicon chromosome
Accession NZ_CP012126
Organism Escherichia coli strain DH1Ec104

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag ADZ27_RS10390 Protein ID WP_000767829.1
Coordinates 2073017..2073271 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag ADZ27_RS10395 Protein ID WP_001259255.1
Coordinates 2073268..2073519 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADZ27_RS10365 2068032..2068259 - 228 WP_000234896.1 sulfurtransferase TusA -
ADZ27_RS10370 2068273..2069331 - 1059 WP_000492339.1 transport protein YeeE -
ADZ27_RS10375 2069510..2070868 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
ADZ27_RS25395 2070858..2070920 - 63 WP_010723108.1 membrane protein YoeI -
ADZ27_RS10380 2071135..2072064 - 930 WP_000803351.1 LysR family transcriptional regulator -
ADZ27_RS10385 2072110..2072934 - 825 WP_000754737.1 SDR family oxidoreductase -
ADZ27_RS10390 2073017..2073271 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ADZ27_RS10395 2073268..2073519 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ADZ27_RS23730 2073802..2073852 + 51 WP_001364200.1 his operon leader peptide -
ADZ27_RS10400 2073998..2074897 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
ADZ27_RS10405 2074903..2076207 + 1305 WP_000009594.1 histidinol dehydrogenase -
ADZ27_RS10410 2076204..2077274 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
ADZ27_RS10415 2077274..2078341 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T55893 WP_000767829.1 NZ_CP012126:c2073271-2073017 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T55893 NZ_CP012126:c2073271-2073017 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT55893 WP_001259255.1 NZ_CP012126:c2073519-2073268 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT55893 NZ_CP012126:c2073519-2073268 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References