Detailed information of TA system TA055818

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2153656..2153994
• Replicon: chromosome
• Accession: NZ_CP012120
• Organism: Staphylococcus aureus strain USA300_2014.C02

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: ACO02_RS11185
• Protein ID: WP_011447039.1
• Coordinates: 2153656..2153832 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2153820..2153994 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACO02_RS11165	2148891..2152676	+	3786	WP_000582165.1	hypothetical protein	-
ACO02_RS11170	2152666..2152818	+	153	WP_001153681.1	hypothetical protein	-
ACO02_RS11175	2152865..2153152	+	288	WP_001040261.1	hypothetical protein	-
ACO02_RS11180	2153210..2153506	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
ACO02_RS11185	2153656..2153832	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2153820..2153994	-	175	-	-	Antitoxin
ACO02_RS11195	2154044..2154298	+	255	WP_000611512.1	phage holin	-
ACO02_RS11200	2154310..2155065	+	756	WP_000861038.1	CHAP domain-containing protein	-
ACO02_RS11205	2155256..2155747	+	492	WP_000919350.1	staphylokinase	-
ACO02_RS11215	2156397..2156732	+	336	Protein_2102	SH3 domain-containing protein	-
ACO02_RS11220	2156827..2157276	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
ACO02_RS11225	2157961..2158311	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
ACO02_RS11230	2158364..2158624	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	2102363..2158311	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T55818 WP_011447039.1 NZ_CP012120:2153656-2153832 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T55818 NZ_CP012120:2153656-2153832 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT55818 NZ_CP012120:c2153994-2153820 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin