Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1689047..1689231 Replicon chromosome
Accession NZ_CP012120
Organism Staphylococcus aureus strain USA300_2014.C02

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag ACO02_RS08580 Protein ID WP_000482650.1
Coordinates 1689047..1689154 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1689171..1689231 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACO02_RS08555 1684409..1684882 + 474 WP_000456489.1 GyrI-like domain-containing protein -
ACO02_RS08560 1685005..1686216 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
ACO02_RS08565 1686398..1687057 - 660 WP_000831298.1 membrane protein -
ACO02_RS08570 1687117..1688259 - 1143 WP_001176863.1 glycerate kinase -
ACO02_RS08575 1688527..1688913 + 387 WP_000779358.1 flippase GtxA -
ACO02_RS08580 1689047..1689154 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1689171..1689231 - 61 - - Antitoxin
ACO02_RS08590 1689782..1691545 + 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
ACO02_RS08595 1691570..1693303 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
ACO02_RS08605 1693534..1693701 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T55809 WP_000482650.1 NZ_CP012120:1689047-1689154 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T55809 NZ_CP012120:1689047-1689154 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT55809 NZ_CP012120:c1689231-1689171 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References