Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1657208..1657731 Replicon chromosome
Accession NZ_CP012120
Organism Staphylococcus aureus strain USA300_2014.C02

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag ACO02_RS08420 Protein ID WP_000074048.1
Coordinates 1657465..1657731 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag ACO02_RS08415 Protein ID WP_000587616.1
Coordinates 1657208..1657465 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACO02_RS08390 1652288..1653481 + 1194 WP_000675401.1 MFS transporter -
ACO02_RS08395 1653705..1654454 - 750 WP_050902358.1 hypothetical protein -
ACO02_RS08400 1654649..1656226 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
ACO02_RS08405 1656394..1656849 - 456 WP_000732082.1 DUF1307 domain-containing protein -
ACO02_RS08410 1656908..1657102 + 195 WP_001790145.1 hypothetical protein -
ACO02_RS08415 1657208..1657465 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ACO02_RS08420 1657465..1657731 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
ACO02_RS08425 1658086..1659162 + 1077 WP_001076671.1 M42 family metallopeptidase -
ACO02_RS08430 1659410..1660072 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
ACO02_RS08435 1660065..1660841 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
ACO02_RS08440 1661237..1662424 + 1188 WP_050902359.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T55808 WP_000074048.1 NZ_CP012120:1657465-1657731 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T55808 NZ_CP012120:1657465-1657731 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT55808 WP_000587616.1 NZ_CP012120:1657208-1657465 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT55808 NZ_CP012120:1657208-1657465 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References