Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1707320..1707504 Replicon chromosome
Accession NZ_CP012119
Organism Staphylococcus aureus strain USA300_2014.C01

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag AC807_RS09480 Protein ID WP_000482650.1
Coordinates 1707397..1707504 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1707320..1707380 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AC807_RS09455 1702850..1703017 - 168 WP_001790576.1 hypothetical protein -
AC807_RS09465 1703248..1704981 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
AC807_RS09470 1705006..1706769 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 1707320..1707380 + 61 - - Antitoxin
AC807_RS09480 1707397..1707504 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
AC807_RS09485 1707638..1708024 - 387 WP_000779358.1 flippase GtxA -
AC807_RS09490 1708292..1709434 + 1143 WP_001176863.1 glycerate kinase -
AC807_RS09495 1709494..1710153 + 660 WP_000831298.1 membrane protein -
AC807_RS09500 1710335..1711546 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
AC807_RS09505 1711669..1712142 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T55803 WP_000482650.1 NZ_CP012119:c1707504-1707397 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T55803 NZ_CP012119:c1707504-1707397 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT55803 NZ_CP012119:1707320-1707380 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References