Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 1417217..1417480 Replicon chromosome
Accession NZ_CP012119
Organism Staphylococcus aureus strain USA300_2014.C01

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag AC807_RS07895 Protein ID WP_001802298.1
Coordinates 1417376..1417480 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 1417217..1417381 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AC807_RS07875 1413400..1414065 - 666 WP_001024094.1 SDR family oxidoreductase -
AC807_RS07880 1414217..1414537 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
AC807_RS07885 1414539..1415519 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
AC807_RS07890 1415785..1416876 + 1092 WP_000495671.1 lytic regulatory protein -
- 1417217..1417381 + 165 - - Antitoxin
AC807_RS07895 1417376..1417480 - 105 WP_001802298.1 hypothetical protein Toxin
AC807_RS15650 1417641..1418124 - 484 Protein_1431 recombinase family protein -
AC807_RS07905 1418167..1419303 - 1137 WP_000115564.1 SAP domain-containing protein -
AC807_RS07910 1419592..1419684 + 93 WP_001790138.1 hypothetical protein -
AC807_RS07915 1420389..1421246 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
AC807_RS07920 1421314..1422096 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T55800 WP_001802298.1 NZ_CP012119:c1417480-1417376 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T55800 NZ_CP012119:c1417480-1417376 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT55800 NZ_CP012119:1417217-1417381 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References