Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 764467..765037 Replicon chromosome
Accession NZ_CP012117
Organism Dermabacter vaginalis strain AD1-86

Toxin (Protein)


Gene name higB Uniprot ID A0A1B0ZH24
Locus tag DAD186_RS03205 Protein ID WP_055089482.1
Coordinates 764756..765037 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3S0SU49
Locus tag DAD186_RS03200 Protein ID WP_065247466.1
Coordinates 764467..764769 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAD186_RS11070 759955..760134 - 180 WP_065247463.1 DUF86 domain-containing protein -
DAD186_RS10955 760181..760351 - 171 WP_164497577.1 hypothetical protein -
DAD186_RS03185 760682..762106 - 1425 WP_065247464.1 hypothetical protein -
DAD186_RS03190 762213..763739 - 1527 WP_065247465.1 Abi family protein -
DAD186_RS03200 764467..764769 - 303 WP_065247466.1 HigA family addiction module antidote protein Antitoxin
DAD186_RS03205 764756..765037 - 282 WP_055089482.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DAD186_RS03210 765461..765782 + 322 Protein_632 hypothetical protein -
DAD186_RS03215 765885..766739 - 855 WP_065247467.1 23S ribosomal RNA methyltransferase Erm -
DAD186_RS11075 767089..767355 - 267 WP_101687314.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island erm(X) - 742841..771538 28697


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10942.45 Da        Isoelectric Point: 10.2909

>T55788 WP_055089482.1 NZ_CP012117:c765037-764756 [Dermabacter vaginalis]
MIRSFGDKATERLWRRERVRSIDPRIHRVALRKLRQVGSAESLEDLRVPPGNRLEALKGDRAGQYSIRINDQWRICFVWS
DAGPEEVQIVDYH

Download         Length: 282 bp

>T55788 NZ_CP012117:c765037-764756 [Dermabacter vaginalis]
ATGATCAGATCGTTCGGCGACAAGGCGACCGAACGGCTGTGGCGTCGTGAGCGCGTGCGGTCCATCGATCCGAGGATCCA
TCGCGTCGCACTGCGCAAGCTGCGTCAGGTGGGGTCCGCGGAGTCTCTCGAGGACCTCCGGGTCCCGCCCGGCAACCGGC
TCGAGGCCCTCAAGGGTGATCGGGCCGGGCAGTACAGCATCAGGATCAACGACCAGTGGCGTATCTGCTTTGTGTGGAGC
GACGCCGGACCGGAGGAGGTGCAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11047.56 Da        Isoelectric Point: 4.8129

>AT55788 WP_065247466.1 NZ_CP012117:c764769-764467 [Dermabacter vaginalis]
MTTTDRIEPIHPGEVLMEDFIGGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSAEFWINLQSHYEL
DRAEDLAEEQIAAITPLQAA

Download         Length: 303 bp

>AT55788 NZ_CP012117:c764769-764467 [Dermabacter vaginalis]
TTGACTACCACTGACAGGATCGAGCCGATCCACCCGGGTGAGGTCCTCATGGAGGACTTCATCGGGGGCTTCGGCATCAC
GCAGAACAAGCTCGCCGTCTCGATCGGGGTTCCGCCGCGGCGGATCAATGAGATTGTGCACGGCAAGCGGGGCATCACTG
CCGACACCGCGCTGCGGCTCGCGAAGTACTTCGGCACGTCGGCGGAGTTCTGGATCAACCTGCAGAGCCACTACGAGCTG
GATCGTGCGGAGGACCTCGCGGAGGAGCAGATCGCGGCGATCACGCCCCTGCAAGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B0ZH24

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0SU49

References