Detailed information of TA system TA055787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-VapI
• Location: 747944..748517
• Replicon: chromosome
• Accession: NZ_CP012117
• Organism: Dermabacter vaginalis strain AD1-86

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A1B0ZH24
• Locus tag: DAD186_RS03115
• Protein ID: WP_055089482.1
• Coordinates: 747944..748225 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DAD186_RS03120
• Protein ID: WP_065247455.1
• Coordinates: 748212..748517 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAD186_RS03095	743674..744768	-	1095	WP_005325330.1	iron chelate uptake ABC transporter family permease subunit	-
DAD186_RS03100	744768..745886	-	1119	WP_019176088.1	iron ABC transporter permease	-
DAD186_RS10580	746214..747218	+	1005	WP_208854274.1	DDE-type integrase/transposase/recombinase	-
DAD186_RS03110	747215..747862	-	648	WP_141742413.1	IS3 family transposase	-
DAD186_RS03115	747944..748225	+	282	WP_055089482.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DAD186_RS03120	748212..748517	+	306	WP_065247455.1	HigA family addiction module antidote protein	Antitoxin
DAD186_RS03125	748514..748954	+	441	WP_065247456.1	HIT domain-containing protein	-
DAD186_RS03130	749192..751084	-	1893	WP_065247457.1	cadmium-translocating P-type ATPase	-
DAD186_RS03135	751081..751440	-	360	WP_065247458.1	metalloregulator ArsR/SmtB family transcription factor	-
DAD186_RS03140	751504..751956	-	453	WP_082991049.1	flavin-dependent oxidoreductase	-
DAD186_RS03145	752199..752582	-	384	WP_065247459.1	MerR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	erm(X)	-	742841..771538	28697
	-	flank	IS/Tn	-	-	747215..747844	629

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (25-71)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10942.45 Da
• Isoelectric Point: 10.2909

>T55787 WP_055089482.1 NZ_CP012117:747944-748225 [Dermabacter vaginalis]
MIRSFGDKATERLWRRERVRSIDPRIHRVALRKLRQVGSAESLEDLRVPPGNRLEALKGDRAGQYSIRINDQWRICFVWS
DAGPEEVQIVDYH

Nucleotide

• Length: 282 bp

>T55787 NZ_CP012117:747944-748225 [Dermabacter vaginalis]
ATGATCAGATCGTTCGGCGACAAGGCGACCGAACGGCTGTGGCGTCGTGAGCGCGTGCGGTCCATCGATCCGAGGATCCA
TCGCGTCGCACTGCGCAAGCTGCGTCAGGTGGGGTCCGCGGAGTCTCTCGAGGACCTCCGGGTCCCGCCCGGCAACCGAC
TCGAGGCCCTCAAGGGTGATCGGGCCGGGCAGTACAGCATCAGGATCAACGACCAGTGGCGTATCTGCTTTGTGTGGAGC
GACGCCGGACCGGAGGAGGTGCAGATCGTTGACTACCACTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11220.73 Da
• Isoelectric Point: 4.8499

>AT55787 WP_065247455.1 NZ_CP012117:748212-748517 [Dermabacter vaginalis]
MTTTDRIEPIHPGEVLMEDFIGGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSAEFWINLQSHYEL
DRAEDLAEEQIAAITPLERAS

Nucleotide

• Length: 306 bp

>AT55787 NZ_CP012117:748212-748517 [Dermabacter vaginalis]
TTGACTACCACTGACAGGATCGAGCCGATCCACCCGGGTGAGGTCCTCATGGAGGACTTCATCGGGGGCTTCGGCATCAC
GCAGAACAAGCTCGCCGTCTCGATCGGGGTTCCGCCGCGGCGGATCAATGAGATTGTGCACGGCAAGCGGGGCATCACTG
CCGACACCGCGCTGCGGCTCGCGAAGTACTTCGGCACGTCGGCGGAGTTCTGGATCAACCTGCAGAGCCACTACGAGCTG
GATCGTGCGGAGGACCTCGCGGAGGAGCAGATCGCGGCGATCACGCCCTTGGAGCGGGCGTCGTGA

Structures

Toxin

• AlphaFold DB: A0A1B0ZH24