Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 592855..593508 Replicon chromosome
Accession NZ_CP012097
Organism Serratia plymuthica strain 3Re4-18

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ADP73_RS02720 Protein ID WP_064798643.1
Coordinates 592855..593205 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ADP73_RS02725 Protein ID WP_013811356.1
Coordinates 593209..593508 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADP73_RS02695 588334..589425 + 1092 WP_063202129.1 dimethyl sulfone monooxygenase SfnG -
ADP73_RS02700 589427..590128 - 702 WP_006323392.1 trehalose-6-phosphate synthase -
ADP73_RS02705 590143..590682 - 540 WP_064798640.1 GNAT family N-acetyltransferase -
ADP73_RS02710 590740..592119 - 1380 WP_064798641.1 glutamine synthetase family protein -
ADP73_RS02715 592375..592689 + 315 WP_064798642.1 hypothetical protein -
ADP73_RS02720 592855..593205 + 351 WP_064798643.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ADP73_RS02725 593209..593508 + 300 WP_013811356.1 helix-turn-helix transcriptional regulator Antitoxin
ADP73_RS02730 593545..594621 - 1077 WP_064798644.1 YncE family protein -
ADP73_RS02735 594907..596175 - 1269 WP_020438388.1 multidrug effflux MFS transporter -
ADP73_RS02740 596175..597398 - 1224 WP_006323398.1 cytochrome P450 -
ADP73_RS02745 597413..597670 - 258 WP_006323399.1 acyl carrier protein -
ADP73_RS02750 597717..598268 - 552 WP_006323400.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13514.59 Da        Isoelectric Point: 7.8898

>T55767 WP_064798643.1 NZ_CP012097:592855-593205 [Serratia plymuthica]
MWTVITTEEFDRWFAVQDELTQEKVLAALVLLERSDPNLSRPFVDSLRGSQHPNMKELRVQHKGRPIRAFFAFDSLRQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQHLMCNFKE

Download         Length: 351 bp

>T55767 NZ_CP012097:592855-593205 [Serratia plymuthica]
ATGTGGACTGTAATAACAACGGAAGAGTTTGATCGGTGGTTTGCGGTGCAGGATGAACTTACGCAGGAGAAAGTGCTGGC
TGCATTAGTATTGCTTGAGCGGAGTGACCCCAACCTCTCACGTCCTTTTGTAGACTCGTTGAGAGGGTCACAGCACCCTA
ATATGAAAGAACTGCGGGTTCAGCATAAAGGGCGGCCGATTCGCGCTTTTTTTGCCTTTGACTCACTACGTCAGGCTATT
GTTTTGTGTGCCGGCGATAAGACCGGTAACGAGAAGCGGTTTTACAAAGTCATGCTGCCTATTGCTGATGCGCAGTTTAC
CCAGCATTTGATGTGTAATTTTAAGGAGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11183.85 Da        Isoelectric Point: 5.1667

>AT55767 WP_013811356.1 NZ_CP012097:593209-593508 [Serratia plymuthica]
MGTLKDMLASRTPESLQRIEEMAQEMWLEARLYQLREALNISQQELANNLGISQPSVAAIEQRGNELKISTLKRYVEAMG
GTLRLDVELPDGKHVGFRV

Download         Length: 300 bp

>AT55767 NZ_CP012097:593209-593508 [Serratia plymuthica]
ATGGGTACTTTAAAAGACATGCTAGCCTCGCGTACCCCGGAGAGTCTGCAACGAATCGAAGAAATGGCGCAAGAAATGTG
GCTGGAAGCACGGTTGTACCAATTGCGTGAGGCGCTGAATATCTCACAGCAGGAACTGGCGAATAATCTGGGTATCTCCC
AGCCTTCCGTCGCGGCGATAGAGCAGCGTGGCAATGAGCTGAAGATATCGACATTGAAGCGCTATGTGGAAGCCATGGGC
GGAACTCTGCGGCTGGATGTCGAGCTGCCGGACGGCAAGCACGTCGGATTTAGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References