Detailed information of TA system TA055568

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 5157359..5157807
• Replicon: chromosome
• Accession: NZ_CP012048
• Organism: Xanthomonas phaseoli pv. phaseoli strain ISO18C2

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: AC609_RS24940
• Protein ID: WP_201417376.1
• Coordinates: 5157667..5157807 (-)
• Length: 47 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AC609_RS23675
• Protein ID: WP_017156025.1
• Coordinates: 5157359..5157649 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AC609_RS23645	5152694..5153026	+	333	WP_003482333.1	hypothetical protein	-
AC609_RS23655	5153341..5155266	+	1926	WP_039574551.1	M61 family metallopeptidase	-
AC609_RS24935	5155334..5155513	+	180	WP_039574549.1	hypothetical protein	-
AC609_RS23665	5155616..5157004	-	1389	WP_039574546.1	nucleoside hydrolase	-
AC609_RS23675	5157359..5157649	-	291	WP_017156025.1	HigA family addiction module antidote protein	Antitoxin
AC609_RS24940	5157667..5157807	-	141	WP_201417376.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AC609_RS23685	5158045..5160552	-	2508	WP_046834789.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	5111333..5181688	70355

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-46)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-94)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5621.49 Da
• Isoelectric Point: 9.1269

>T55568 WP_201417376.1 NZ_CP012048:c5157807-5157667 [Xanthomonas phaseoli pv. phaseoli]
IPPANRLEALKGERRGQYRIRINDRWRICVRWMEGDVVQVEIIDYH

Nucleotide

• Length: 141 bp

>T55568 NZ_CP012048:c5157807-5157667 [Xanthomonas phaseoli pv. phaseoli]
ATCCCGCCCGCCAACCGGCTGGAAGCGTTGAAGGGCGAGCGGCGCGGCCAGTACCGCATCCGGATCAACGATCGATGGCG
CATCTGCGTCCGATGGATGGAAGGCGATGTGGTCCAGGTCGAAATCATCGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10387.09 Da
• Isoelectric Point: 9.0188

>AT55568 WP_017156025.1 NZ_CP012048:c5157649-5157359 [Xanthomonas phaseoli pv. phaseoli]
MTVLPNIHPGAILLEEFLQPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTFERFWLGLQADDELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT55568 NZ_CP012048:c5157649-5157359 [Xanthomonas phaseoli pv. phaseoli]
ATGACGGTCCTGCCCAATATCCACCCTGGCGCAATTCTGCTTGAGGAGTTTCTCCAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGAACCTTCGAGCGCTTCTGGCTTGGCCTGCAGGCCGACGACGAGCTGGAGCAGGCG
CATCGCGCGCTGGGCGACTTGCCGGCGCGGATCAAGCGGCTGGCGGCATGA