Detailed information of TA system TA055532

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 1199025..1199878
• Replicon: chromosome
• Accession: NZ_CP012019
• Organism: Legionella pneumophila subsp. pneumophila strain Toronto-20052

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: lpt_RS05310
• Protein ID: WP_042754999.1
• Coordinates: 1199025..1199531 (-)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: lpt_RS05315
• Protein ID: WP_042754998.1
• Coordinates: 1199531..1199878 (-)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
lpt_RS05290	1194112..1194921	-	810	WP_042755003.1	integrase domain-containing protein	-
lpt_RS16640	1195323..1195511	+	189	WP_136629085.1	hypothetical protein	-
lpt_RS05295	1195525..1197297	-	1773	WP_042755002.1	ATP-binding protein	-
lpt_RS05300	1197491..1197754	+	264	WP_042755001.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
lpt_RS16200	1197833..1197999	+	167	Protein_1042	type II toxin-antitoxin system YafQ family toxin	-
lpt_RS05305	1198290..1198649	+	360	WP_042755000.1	MarR family transcriptional regulator	-
lpt_RS05310	1199025..1199531	-	507	WP_042754999.1	type II toxin-antitoxin system YhaV family toxin	Toxin
lpt_RS05315	1199531..1199878	-	348	WP_042754998.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
lpt_RS05320	1199948..1201198	-	1251	WP_061784227.1	tyrosine-type recombinase/integrase	-
lpt_RS16205	1201547..1202049	+	503	Protein_1047	transposase	-
lpt_RS05335	1202113..1203281	+	1169	WP_105625152.1	IS3 family transposase	-
lpt_RS05340	1203573..1204241	+	669	WP_061636258.1	HAD family phosphatase	-
lpt_RS05345	1204395..1204601	+	207	WP_061636257.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (14-150)

Antitoxin

• PrlF antitoxin (8-105)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 19527.21 Da
• Isoelectric Point: 9.5699

>T55532 WP_042754999.1 NZ_CP012019:c1199531-1199025 [Legionella pneumophila subsp. pneumophila]
MVDNSIITINGWVILCHPLFLQQVEALANEVEKAKEKDPSNFHTRNSTKKLAAIAKLAFEKIPNDPAATEFRQGSTLGNN
HKHWFRAKFFQQYRLFFRYHQESKIIIYAWVNDDSSKRAYESKADAYHIFRKMLENGHPPDNWDELLKEANNTSLMKKLT
TSLDALKS

Nucleotide

• Length: 507 bp

>T55532 NZ_CP012019:c1199531-1199025 [Legionella pneumophila subsp. pneumophila]
ATGGTTGATAATTCAATAATAACAATAAATGGCTGGGTTATTTTATGCCATCCTCTTTTTTTGCAACAGGTAGAGGCATT
GGCTAATGAGGTAGAAAAAGCAAAAGAAAAGGACCCTTCAAATTTTCATACACGAAACTCGACAAAAAAATTAGCAGCCA
TTGCTAAATTAGCTTTTGAAAAAATTCCAAACGATCCTGCAGCTACAGAATTTCGACAAGGATCAACATTAGGAAATAAC
CACAAACATTGGTTTCGAGCTAAATTTTTTCAGCAATATCGATTATTTTTTAGATACCATCAAGAAAGTAAAATAATTAT
TTATGCTTGGGTTAATGATGACAGTTCTAAAAGAGCATATGAAAGTAAAGCAGATGCTTATCATATTTTTCGAAAGATGC
TGGAAAATGGTCATCCTCCAGATAATTGGGATGAATTACTTAAAGAAGCAAATAACACTTCGTTAATGAAAAAATTGACT
ACCAGTTTGGATGCTTTGAAAAGTTAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 13175.84 Da
• Isoelectric Point: 4.9405

>AT55532 WP_042754998.1 NZ_CP012019:c1199878-1199531 [Legionella pneumophila subsp. pneumophila]
MARLLQTESTLTDRYQTTVPDAVRKALHLGKRDKIRYTVQSDGHVLMTRAEKEEDPVIAEFLNFIAKDIQNNPKNLTTIN
QDLVTRINSLVANVEVNLDEPLTEDEQLTENRVSR

Nucleotide

• Length: 348 bp

>AT55532 NZ_CP012019:c1199878-1199531 [Legionella pneumophila subsp. pneumophila]
ATGGCTAGATTACTACAAACCGAATCCACCCTCACAGATCGTTATCAAACAACTGTACCAGATGCTGTGAGAAAAGCCCT
GCATCTAGGAAAAAGAGATAAAATTCGATACACCGTTCAATCTGACGGTCATGTTCTTATGACTCGAGCAGAGAAAGAGG
AAGATCCAGTAATTGCTGAATTTTTGAATTTCATTGCTAAAGACATTCAAAATAACCCCAAAAATCTGACAACTATAAAT
CAGGATTTAGTAACTCGCATCAACTCTTTAGTTGCAAATGTTGAAGTCAATTTAGATGAACCTTTAACCGAGGATGAACA
ATTAACTGAAAACCGAGTAAGTCGCTAA