Detailed information of TA system TA055518

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2178473..2178772
• Replicon: chromosome
• Accession: NZ_CP012018
• Organism: Staphylococcus aureus strain Gv88

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: SAGV88_RS16035
• Protein ID: WP_078156886.1
• Coordinates: 2178596..2178772 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2178473..2178528 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV88_RS11135	2175152..2175601	+	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
SAGV88_RS16390	2175696..2176031	-	336	Protein_2123	SH3 domain-containing protein	-
SAGV88_RS11145	2176681..2177172	-	492	WP_000919350.1	staphylokinase	-
SAGV88_RS11150	2177363..2178118	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAGV88_RS11155	2178130..2178384	-	255	WP_000611512.1	phage holin	-
SAGV88_RS11160	2178436..2178543	+	108	Protein_2127	hypothetical protein	-
-	2178465..2178604	+	140	NuclAT_0	-	-
-	2178465..2178604	+	140	NuclAT_0	-	-
-	2178465..2178604	+	140	NuclAT_0	-	-
-	2178465..2178604	+	140	NuclAT_0	-	-
-	2178473..2178528	+	56	-	-	Antitoxin
SAGV88_RS16035	2178596..2178772	-	177	WP_078156886.1	putative holin-like toxin	Toxin
SAGV88_RS11165	2178922..2179218	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SAGV88_RS11170	2179276..2179563	-	288	WP_001040261.1	hypothetical protein	-
SAGV88_RS11175	2179610..2179762	-	153	WP_001153681.1	hypothetical protein	-
SAGV88_RS11180	2179752..2183537	-	3786	WP_000582158.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb	2172787..2218303	45516
	-	flank	IS/Tn	-	-	2173201..2174373	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6873.43 Da
• Isoelectric Point: 10.6777

>T55518 WP_078156886.1 NZ_CP012018:c2178772-2178596 [Staphylococcus aureus]
MDRWWLSEYKEVVSMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T55518 NZ_CP012018:c2178772-2178596 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGTCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT55518 NZ_CP012018:2178473-2178528 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin