Detailed information of TA system TA055515

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2016413..2016595
• Replicon: chromosome
• Accession: NZ_CP012018
• Organism: Staphylococcus aureus strain Gv88

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SAGV88_RS16365
• Protein ID: WP_001801861.1
• Coordinates: 2016413..2016508 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2016536..2016595 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV88_RS10130	2012073..2012699	+	627	WP_000669046.1	hypothetical protein	-
SAGV88_RS10135	2012740..2013084	+	345	WP_000627551.1	DUF3969 family protein	-
SAGV88_RS10140	2013182..2013733	+	552	WP_000414205.1	hypothetical protein	-
SAGV88_RS10145	2013951..2014592	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
SAGV88_RS10150	2014706..2014891	-	186	WP_000809857.1	hypothetical protein	-
SAGV88_RS10155	2014893..2015069	-	177	WP_000375476.1	hypothetical protein	-
SAGV88_RS10160	2015080..2015463	-	384	WP_000070811.1	hypothetical protein	-
SAGV88_RS10170	2016067..2016210	-	144	WP_001549059.1	transposase	-
SAGV88_RS16365	2016413..2016508	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2016536..2016595	-	60	-	-	Antitoxin
SAGV88_RS10175	2016631..2016732	+	102	WP_001791893.1	hypothetical protein	-
SAGV88_RS15950	2016710..2016886	-	177	Protein_1968	transposase	-
SAGV88_RS10180	2017080..2017457	-	378	WP_001037045.1	DUF1433 domain-containing protein	-
SAGV88_RS10185	2017978..2019303	-	1326	Protein_1970	ATP-binding protein	-
SAGV88_RS10190	2019407..2020579	+	1173	WP_000195429.1	IS256-like element IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1985313..2052436	67123
	-	inside	Prophage	-	lukD / hlgA	1983150..2049766	66616
	-	flank	IS/Tn	-	-	2019407..2020579	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T55515 WP_001801861.1 NZ_CP012018:2016413-2016508 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T55515 NZ_CP012018:2016413-2016508 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT55515 NZ_CP012018:c2016595-2016536 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin