Detailed information of TA system TA055511

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1678317..1678896
• Replicon: chromosome
• Accession: NZ_CP012018
• Organism: Staphylococcus aureus strain Gv88

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAGV88_RS08430
• Protein ID: WP_001025401.1
• Coordinates: 1678651..1678896 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1678317..1678682 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV88_RS08390	1675060..1675617	-	558	WP_000645042.1	DUF2815 family protein	-
SAGV88_RS08395	1675643..1676809	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
SAGV88_RS08400	1676806..1677168	-	363	WP_000985984.1	hypothetical protein	-
SAGV88_RS08405	1677183..1677506	-	324	WP_000175001.1	hypothetical protein	-
SAGV88_RS08410	1677585..1677746	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
SAGV88_RS08415	1677759..1678022	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
SAGV88_RS08420	1678047..1678262	-	216	WP_001097552.1	hypothetical protein	-
SAGV88_RS08425	1678317..1678682	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SAGV88_RS08430	1678651..1678896	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAGV88_RS08435	1678952..1679161	+	210	WP_000642492.1	hypothetical protein	-
SAGV88_RS08440	1679151..1679294	-	144	WP_000939498.1	hypothetical protein	-
SAGV88_RS08445	1679323..1680099	-	777	WP_001148544.1	Rha family transcriptional regulator	-
SAGV88_RS08450	1680113..1680349	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
SAGV88_RS08455	1680501..1680815	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
SAGV88_RS08460	1680828..1681289	+	462	WP_000525004.1	hypothetical protein	-
SAGV88_RS08465	1681307..1681891	+	585	WP_000825948.1	hypothetical protein	-
SAGV88_RS08470	1682121..1682267	+	147	WP_001013104.1	hypothetical protein	-
SAGV88_RS08475	1682264..1682878	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ebp	1629560..1701840	72280

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T55511 WP_001025401.1 NZ_CP012018:c1678896-1678651 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T55511 NZ_CP012018:c1678896-1678651 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT55511 NZ_CP012018:1678317-1678682 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin